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中华肾病研究电子杂志 ›› 2024, Vol. 13 ›› Issue (03) : 166 -169. doi: 10.3877/cma.j.issn.2095-3216.2024.03.007

综述

甲基苯丙胺相关肾损害的机制与治疗研究进展
禹杭远1, 王月琪2, 张英霞1, 张利1, 周艳1, 刘畅1, 李元子3,()   
  1. 1. 102600 北京市利康教育矫治所
    2. 100032 北京,中国自然资源经济研究院
    3. 100020 首都医科大学附属北京朝阳医院
  • 收稿日期:2023-04-04 出版日期:2024-06-28
  • 通信作者: 李元子

Research progress on mechanism and treatment of methamphetamine-related kidney injury

Hangyuan Yu1, Yueqi Wang2, Yingxia Zhang1, Li Zhang1, Yan Zhou1, Chang Liu1, Yuanzi Li3,()   

  1. 1. Li Kang Compulsory Isolation Drug Rehabilitation Center of Beijing, Beijing 102600
    2. Chinese Academy of Natural Resources Economics, Beijing 100032
    3. Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing 100020; China
  • Received:2023-04-04 Published:2024-06-28
  • Corresponding author: Yuanzi Li
引用本文:

禹杭远, 王月琪, 张英霞, 张利, 周艳, 刘畅, 李元子. 甲基苯丙胺相关肾损害的机制与治疗研究进展[J]. 中华肾病研究电子杂志, 2024, 13(03): 166-169.

Hangyuan Yu, Yueqi Wang, Yingxia Zhang, Li Zhang, Yan Zhou, Chang Liu, Yuanzi Li. Research progress on mechanism and treatment of methamphetamine-related kidney injury[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2024, 13(03): 166-169.

甲基苯丙胺是一种高度成瘾性的拟交感神经制剂,主要在肝脏代谢并通过肾脏排出体外。甲基苯丙胺除具有神经毒性作用外,还可导致急性肾功能衰竭和慢性肾功能不全,其机制包括肾血管损伤、高热、电解质紊乱、非创伤性横纹肌溶解和直接肾毒性等。甲基苯丙胺相关肾损害的初期症状不明显,待确诊时往往已经出现了肾脏器质性改变。因此,早期评估和干预是降低甲基苯丙胺相关肾损害的关键。本文综述了甲基苯丙胺相关肾损害的作用机制与治疗研究进展。

Methamphetamine is a highly addictive sympathomimetic agent that is metabolized primarily in the liver and excreted through the kidneys. In addition to neurotoxic effects, methamphetamine can also lead to acute renal failure and chronic renal insufficiency through mechanisms including renal vascular injury, hyperthermia, electrolyte disturbance, non-traumatic rhabdomyolysis, and direct renal toxicity, etc. The initial symptoms of methamphetamine-related kidney injury are not obvious, and by the time when it is diagnosed, changes in the kidneys are often already present. Therefore, early assessment and intervention are key to reducing methamphetamine-related kidney injury. This article reviewed the research progress on the mechanism and treatment of methamphetamine-related kidney injury.

图1 甲基苯丙胺相关性肾损害机制
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