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中华肾病研究电子杂志 ›› 2021, Vol. 10 ›› Issue (03) : 138 -143. doi: 10.3877/cma.j.issn.2095-3216.2021.03.004

论著

新冠病毒感染患者并发急性肾损伤与临床预后相关性的Meta分析
罗晴1, 彭婷2, 张伟光3, 程晓巍1, 王滨4,(), 陈意志4,()   
  1. 1. 572013 三亚,解放军总医院海南医院肾脏病科,海南省院士团队创新中心
    2. 572013 海南省三亚市中医院内二科
    3. 100853 北京,解放军总医院第一医学中心肾脏病医学部,解放军肾脏病研究所,肾脏疾病国家重点实验室,国家慢性肾病临床医学研究中心,肾脏疾病研究北京市重点实验室
    4. 572013 三亚,解放军总医院海南医院肾脏病科,海南省院士团队创新中心;100853 北京,解放军总医院第一医学中心肾脏病医学部,解放军肾脏病研究所,肾脏疾病国家重点实验室,国家慢性肾病临床医学研究中心,肾脏疾病研究北京市重点实验室
  • 收稿日期:2020-08-24 出版日期:2021-06-28
  • 通信作者: 王滨, 陈意志
  • 基金资助:
    海南省院士创新平台科研专项(YSPTZX202026)

Meta analysis of the correlation between acute kidney injury and clinical prognosis in patients with SARS-CoV-2 infection

Qing Luo1, Ting Peng2, Weiguang Zhang3, Xiaowei Cheng1, Bin Wang4,(), Yizhi Chen4,()   

  1. 1. Department of Nephrology, Hainan Hospital of Chinese PLA General Hospital, Hainan Academician Team Innovation Center
    2. Department of Internal Medicine II, Sanya Hospital of Traditional Chinese Medicine; Sanya 572013, Hainan Province
    3. Department of Nephrology, First Medical Center of Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases, Beijing 100853; China
    4. Department of Nephrology, Hainan Hospital of Chinese PLA General Hospital, Hainan Academician Team Innovation Center; Department of Nephrology, First Medical Center of Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases, Beijing 100853; China
  • Received:2020-08-24 Published:2021-06-28
  • Corresponding author: Bin Wang, Yizhi Chen
引用本文:

罗晴, 彭婷, 张伟光, 程晓巍, 王滨, 陈意志. 新冠病毒感染患者并发急性肾损伤与临床预后相关性的Meta分析[J/OL]. 中华肾病研究电子杂志, 2021, 10(03): 138-143.

Qing Luo, Ting Peng, Weiguang Zhang, Xiaowei Cheng, Bin Wang, Yizhi Chen. Meta analysis of the correlation between acute kidney injury and clinical prognosis in patients with SARS-CoV-2 infection[J/OL]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2021, 10(03): 138-143.

目的

系统评价并且定量分析感染新冠病毒患者病程中急性肾损伤(AKI)的发生率及其同临床预后的关系。

方法

通过检索中国知网、维普、万方、中国生物医学文献数据库(CBM)、PubMed和Embase的文献,依据NOS质量评价表进行质量评价,由2研究者独立提取数据,采用Review Manager 5.3软件对所得的数据进行Meta分析。

结果

共纳入17篇文献,Meta分析结果表明,感染新冠病毒患者出现AKI后进展为重症病例的风险显著增加(OR=10.25,95%CI:7.79~13.49,P<0.01),死亡风险亦显著增加(OR=24.38,95%CI:4.87~22.04,P<0.01)。

结论

新冠病毒感染患者的AKI总体发生率并不高,但AKI会增加新冠肺炎患者进展为重症及死亡的概率,因此一旦出现AKI应立即重视并给予相应的处置。

Objective

To systematically evaluate and quantitatively analyze the incidence of AKI in patients with SARS-CoV-2 infection and the relationship between the AKI and clinical prognosis.

Methods

After retrieving databases of CNKI, Weipu, Wanfang, China Biomedical Literature Database (CBM), PubMed, and Embase, the literature quality evaluation was carried out according to the the Newcastle-Ottawa scale (NOS) quality evaluation table. The data was extracted by 2 researchers independently, and the Review Manager 5.3 software was used for the meta-analysis of the obtained data.

Results

A total of 17 studies were included. The meta-analysis results showed that if the patients with SARS-CoV-2 infection had new-onset AKI, they had significantly increased risks of progression to severe cases (OR=10.25, 95%CI: 7.79-13.49, P<0.01) or death (OR=24.38, 95%CI: 4.87-122.04, P<0.01).

Conclusion

The overall incidence of AKI in patients with SARS-CoV-2 infection was not high, but the AKI increased their probability of progressing to severe cases or death. Therefore, once AKI appeared, attention should be paid immediately and corresponding treatment should be given to the patients.

图1 纳入文献筛选流程图
表1 纳入荟萃分析文献的基本情况
表2 文献质量评价表(NOS)
图2 感染新冠病毒患者疾病严重程度同AKI发生之间关系(Meta分析)
图3 13篇新冠肺炎患者发生AKI Meta分析文献发表偏倚分析
图4 感染新冠病毒患者死亡与AKI发生率的关系(Meta分析)
图5 感染新冠病毒患者死亡及AKI发生率关系的亚组分析(Meta分析)
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