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中华肾病研究电子杂志 ›› 2024, Vol. 13 ›› Issue (05) : 291 -295. doi: 10.3877/cma.j.issn.2095-3216.2024.05.010

病例报告

集成血液净化联合利妥昔单抗治疗抗中性粒细胞胞浆抗体伴抗肾小球基底膜抗体阳性的血管炎患者:一例报告及文献复习
朱合1, 徐佳1, 尤永珂1, 宋佚凡1, 陈利婷1, 任野萍1, 王琴1,()   
  1. 1.518055 深圳大学总医院肾脏病科
  • 收稿日期:2023-12-28 出版日期:2024-10-28
  • 通信作者: 王琴
  • 基金资助:
    国家自然科学基金项目(82270774)

Integrated blood purification combined with rituximab in the treatment of a vasculitis patient positive for both ANCA and anti- GBM antibody:a case report with literature review

He Zhu, Jia Xu, Yongke You, Yifan Song, Liting Chen, Yeping Ren, Qin Wang()   

  • Received:2023-12-28 Published:2024-10-28
  • Corresponding author: Qin Wang
引用本文:

朱合, 徐佳, 尤永珂, 宋佚凡, 陈利婷, 任野萍, 王琴. 集成血液净化联合利妥昔单抗治疗抗中性粒细胞胞浆抗体伴抗肾小球基底膜抗体阳性的血管炎患者:一例报告及文献复习[J]. 中华肾病研究电子杂志, 2024, 13(05): 291-295.

He Zhu, Jia Xu, Yongke You, Yifan Song, Liting Chen, Yeping Ren, Qin Wang. Integrated blood purification combined with rituximab in the treatment of a vasculitis patient positive for both ANCA and anti- GBM antibody:a case report with literature review[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2024, 13(05): 291-295.

图1 患者肾组织病理 注:A:IgA 沿系膜区呈逗点状沉积(免疫荧光×400);B:可见细胞纤维性新月体形成(PAS ×400);C:基底膜节段性增厚,脏层上皮细胞肿胀,空泡变性,足突节段性融合,系膜区可见电子致密物沉积(电镜×8 000)
图2 患者血清肌酐水平,抗MPO-IgG 抗体水平、抗GBM-IgG 抗体水平变化曲线图
图3 患者24 h 尿蛋白定量水平变化曲线图
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