Mechanisms of injury and repair of acute kidney injury

doi:10.3877/cma.j.issn.2095-3216.2013.03.003

Abstract

Abstract:

The renal tubular epithelium, the endothelium of microvessels and the inflammatory cells are the three major components of the complicated mechanisms that are involved in the process of tissue injury and repair during acute kidney injury (AKI). The renal tubular epithelial cells are not only the major target of injury, but also modulate inflammatory responses through secreting various cytokines. The maladaptive repair of tubular epithelial cells after AKI initiates interstitial fibrosis. The continuous loss of endothelium of microvessels induces chronic ischemia and hypoxia in the tubulointerstitial compartment,which promotes the progression of fibrosis. The sustained activation of monocytes/macrophages also devotes to the process of fibrosis.

Key words: Acute kidney injury; Repair; Renal tubular epithelium; Microvessels; Inflammation

Li YANG. Mechanisms of injury and repair of acute kidney injury[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2013, 02(03): 120-125.

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