Abstract:

Drugs are a double-edged sword, which can both treat the disease and cause damage to kidney and other organs. The predisposing factors of drug-induced renal injury include lack of effective volume of circulating blood, the original kidney damage, the elderly, and the joint use of nephrotoxic drugs. Early drug-induced renal injury may not show obvious symptoms, signs, or only show abnormal levels of biomarkers such as urinary neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (Kim-1), and interleukin-18 (IL-18 ), etc. During the course of medication, regular test of these indicators will help early detection of drug-induced renal injury. To prevent or reduce drug-induced renal injury, we should be familiar with the drug features, adverse drug reactions as well as the patients' physical condition, strictly control the medication indications, and adhere to rational use of drugs.

Key words: Drugs, Acute kidney injury, Predisposing factor, Prevention