Helicobacter pylori infection and the development and progression of IgA nephropathy

doi:10.3877/cma.j.issn.2095-3216.2014.02.004

Abstract

Abstract:

IgA nephropathy is the most common primary glomerular disease worldwide which is recognized as a kind of immune-mediated inflammatory disease although its pathogenesis is not clear yet.Helicobacter pylori (Hp) is a kind of microaerobic gram-negative bacterium colonized in human gastrointestinal tract. Hp infection can cause acute or chronic immune inflammation. In recent years, it has been found that there is a certain relationship between Hp infection and IgA nephropathy, and that Hp is likely to be one of the potential pathogenic agents of IgA nephropathy, and related research has become a hot spot of academia. Whether Hp infection is associated with the development and progression of IgA nephropathy has become a hot spot of research. This review will discuss HP infection and pathological mechanism of IgA nephropathy, synthesizing domestic and international results including our own.

Key words: Helicobacter pylori, IgA nephropathy, Pathogenesis

Xin Ma, Junming Fan. Helicobacter pylori infection and the development and progression of IgA nephropathy[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2014, 03(02): 73-76.

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References 16

1	Suzuki H,Marshall BJ,Hibi T. Overview:Helicobacter pylori and extragastric disease[J].Int J Hematol,2006,84(4):291-300.
2	Brandt S, Kwok T, Hartig R, et al. NF-κB activation and potentiation of proinflammatory responses by the Helicobacter pylori CagA protein [J]. Proc Natl Acad Sci USA, 2005, 102(26):9300-9305.
3	Moss SF, Sordillo EM, Abdalla AM, et al. Increased gastric epithelial cell apoptosis associated with colonization with CagA+Helicobacter pylori strains [J]. Cancer Res,2001,61(4): 1406-1411.
4	Nagashima R, Maeda K, Yuda F, et al.Helicobacter pylori antigen in the glomeruli of patients with membranous nephropathy [J].Virchows Arch,1997,431(4):235-239.
5	Cocchiara G, Romano M, Buscemi G, et al. Advantage of eradication therapy for Helicobacter pylori before kidney transplantation in uremic patients [J]. Transplant Proc,2007,39(10):3041-3043.
6	伏莲. 幽门螺杆菌感染相关疾病[J].中国医刊,2007,42 (2):17-18.
7	Sipiczki T, Ondrik Z, et al. The incidence of renal diseases as diagnosed by biopsy in Hungary [J]. Orv Heti, 2004, 145(26):1373-1379.
8	Pipili C, Michopoulos S, Sotiropoulou M, et al. Is there any association between IgA nephropathy, Crohn's disease and Helicobacter pylori infection [J]? Renal Failure, 2012, 34(4):506-509.
9	Barratt J, Bailey EM, Buck KS, et al. Exaggerated systemic antibody response to mucosal Helicobacter pylori infection in IgA nephropathy [J].Am J Kidney Dis,1999,33(6):1049-1057.
10	Nagashima R, Maeda K, Yuda F, et al.Helicobacter pylori antigen in the glomeruli of patients with membranous nephropathy [J].Virchows Arch,1997,431(4):235-239.
11	Kenichiro K, Akiral, Kazuma F, et al. Coccoid Helicobacter pylori exists in the palatine tonsils of patients with IgA nephropathy [J].J Gastroenterol,2010,45(4):406-412.
12	Novak J, Szekanecz Z, Sebesi J, et al. Elevated levels of anti-Helicobacter pylori antibodies in Henoeh-Schnlein purpura [J].Autoimmunity,2003,36(5):307-311.
13	Suzuki H, Kiryluk K, Novak J, et al. The pathophysiology of IgA nephropathy [J]. J Am Soc Nephrol,2011,22(10):1795-1803.
14	Mariotti AJ, Agrawal R, Hotaling AJ. The role of tonsillectomy in pediatric IgA nephropathy [J]. Arch Otolaryngol Head Neck Surg,2009,135(1):85-87.
15	Yang M, Li FG, Xie XS, et al. CagA, a major virulence factor of Helicobacter pylori, promotes the production and underglycosylation of IgA1 in DAKIKI cells. Biochem Biophys Res Commun, 2014,444(2):276-281.
16	杨青梅,鲍晓荣. 幽门螺杆菌及IL-17 高表达与原发性IgA 肾病的关系[J]. 临床内科杂志,2013,30(2):95-97.

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