Abstract:

Drug therapy is one of the most important managements for patients with chronic kidney disease (CKD). It should be emphasized that drug treatment be applied early, synthetically, sustainably,and individually. Attention should also be paid to the changes in pharmacokinetics and pharmacodynamics of drug in CKD patients. The drug pharmacokinetics change was especially significant in CKD patients with moderate-to-severe decrease of glomerular filtration rate (GFR) (CKD stage 3b-5), and in CKD stage 5 patients undergoing dialysis therapy, when dosages of many drugs may need to be adjusted, most of which should be reduced, in order to assure both safety and efficacy of the drugs used.

Key words: Chronic kidney disease, Treatment, Drug, Rational use