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Chinese Journal of Kidney Disease Investigation(Electronic Edition) ›› 2014, Vol. 03 ›› Issue (05): 268-271. doi: 10.3877/cma.j.issn.2095-3216.2014.05.009

• Review • Previous Articles     Next Articles

Role of autophagy in pathogenesis of kidney diseases

Feng Shao1, Xueyuan Bai1,(), Xiangmei Chen1, Yongquan Liu1   

  1. 1.Department of Nephrology, Chinese People's Liberation Army General Hospital, Chinese People's Liberation Army Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing 100853, China
  • Online:2014-10-15 Published:2024-11-28
  • Contact: Xueyuan Bai

Abstract:

Autophagy generally exists in eukaryotic cells, and is an intracellular degradation system dependent on lysosomes. Autophagy is an adaptive metabolic response, can eliminate damaged or senile organelles and biological macromolecules in the cell. It is a kind of highly conservative and important regulatory mechanism to maintain steady state of cells. In recent years, studies showed that autophagy was associated with acute kidney injury, drug-induced renal damage, hereditary kidney disease, diabetic nephropathy, and renal senescence. Therefore, autophagy may be a novel therapeutic target of kidney diseases in the future.

Key words: Autophagy, Phagophore, Lysosome, Kidney disease

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