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Chinese Journal of Kidney Disease Investigation(Electronic Edition) ›› 2014, Vol. 03 ›› Issue (05): 272-274. doi: 10.3877/cma.j.issn.2095-3216.2014.05.010

• Review • Previous Articles     Next Articles

Role of cellular senescence and apoptosis in kidney development

Qinggang Li1,(), Yuansheng Xie1, Xiangmei Chen1   

  1. 1.Department of Nephrology, Chinese People's Liberation Army General Hospital, Chinese People's Liberation Army Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing 100853, China
  • Online:2014-10-15 Published:2024-11-28
  • Contact: Qinggang Li

Abstract:

Senescence is a normal process in the embryonic development, which is involved in embryonic tissue remodeling, tissue development, and morphogenesis, as a programmed aging mechanism during development. As different cellular processes, senescence and apoptosis are closely related to each other. Apoptosis plays an important role during the ureter development. Apoptosis in common nephric duct(CND) occurs normally during development to make the ureteral orifice separate from Wolffian duct (WD)and then fuse with the bladder epithelium, which leads to normal ureter development.

Key words: Developmentally programmed senescence, Kidney development, Cellular apoptosis

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