Multiple myeloma (MM) is a malignant disease with abnormal proliferation of plasma cells, often accompanied with renal impairment (RI), hypercalcemia, bone disease, hyperviscositemia, anemia, infection, thrombosis, etc. Patients with RI account for about 50% of MM. Most RI manifested as cast nephropathy, of which about 9% need dialysis treatment. The western medicine treatment for RI of MM mainly includes adequate hydration, avoidance of using agents that contribute to renal damage, plasma exchange, hemodialysis, chemotherapy for primary disease, and stem cell transplantation; while the traditional Chinese medicine treatment for RI of MM is based on the western medicine treatment, providing treatment on the base of syndrome differentiation, the main effects of which were comprised of enhancing immunity, improving chemotherapy sensitivity, promoting recovery of normal hematopoietic function, reducing subjective symptoms, and decreasing complications of western medicine treatment.