Progress of research on the role of programmed cell death in the pathogenesis of diabetic nephropathy

doi:10.3877/cma.j.issn.2095-3216.2015.04.010

Abstract

Abstract:

Diabetic nephropathy (DN) is a common microvascular complication of diabetes, and its pathogenesis is not entirely clear yet. It has been reported that programmed cell death (PCD) is closely associated with the pathogenesis of DN through pathways including endoplasmic reticulum stress, mitochondrial dysfunction, glycosylation products toxicity, and glycogen synthase kinase GSK3, which can lead to autophagy dysfunction, apoptosis increase of renal inherent cells, and PCD of some potential new types of cells. This review summarized the current domestic and international research data of this field.

Key words: Programmed cell death, Diabetic nephropathy, Pathogenesis

Weihua Wu. Progress of research on the role of programmed cell death in the pathogenesis of diabetic nephropathy[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2015, 04(04): 212-214.

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