With the increasing incidence of diabetes mellitus (DM) year by year, diabetic nephropathy (DN) has become one of the major causes of end-stage renal disease in the world. Therefore, its medical treatment has become the focus of attention. Recently, new advancements in evidence-based treatment of DN have been shown in reasonably controlling hyperglycemia, hypertension, dyslipidemia, reducing proteinuria, and protecting renal function. These measures have updated the previous recognition of treatments, and have significant clinical value in prevention and treatment of complications, slowing down the progression of DN, and reducing the incidence of cardiovascular diseases and death. Here we reviewed the new advancements of evidenced-based treatment of diabetic nephropathy according to the related publications.