In the last 20 years, the population of overweight and obesity has been growing rapidly. And obesity-related glomerulopathy (ORG), which can be directly induced by obesity, has received more and more attention. The pathogenesis of ORG is complex, including hemodynamic dysfunction, kidney hypoxia, insulin resistance, over-activation of sympathetic nerve, and so on, in which podocyte injury appears to play a central role. The typical renal histologic features of ORG consisted of simple obesity-associated glomerular hypertrophy, and obesity- associated focal segmental glomerulosclerosis. The most striking clinical characteristic of ORG is the existence of massive proteinuria with very low incidence of nephrotic syndrome. The treatment for ORG mainly aims at the proper control of the associated risk factors, such as weight control, ameliorating insulin resistance, inhibiting over-activation of RAAS, etc, in order to delay the deterioration of renal functions.