Steroid-resistant nephrotic syndrome (SRNS) is one of the most common and difficult clinical kidney diseases, and is referred to as refractory nephrotic syndrome because the conventional treatment is often ineffective to it. More and more scholars are investigating the integrative Chinese and western medicine therapies in order to improve clinical efficacy and ease side effects caused by long-term high-dose immunosuppressive agents. According to their own experience and the literature review, the authors proposed that attention should be paid to the standardized treatment of refractory NS, as well as the application of kidney collaterals theory from traditional Chinese medicine (TCM) in treatment of SRNS, which is worth using as reference.