Patients with nephrotic syndrome (NS) are in a hypercoagulable state, and prone to suffering from thromboembolic diseases due to endothelial cell damage, coagulation system activation, anti-coagulation dysfunction, weakened fibrinolytic system function, platelet hyperfunction, and the use of glucocorticoids. In traditional Chinese medicine (TCM) theory, the basic mechanisms of hypercoagulability in nephrotic syndrome includes spleen and kidney deficiency as the primary, and blood stasis and others as both the secondary and excess. The TCM treatment, based on syndrome differentiation and combination of disease differentiation and syndrome differentiation, may have good clinical efficacy for it.