Pathogenesis of IgA nephropathy: abnormal glycosylation of IgA1 and abnormal immunity

doi:10.3877/cma.j.issn.2095-3216.2017.04.010

Abstract

Abstract:

IgA nephropathy (IgAN) is the most common glomerulonephritis in the world. Recent researches showed that the galactose-deficient IgA1 (Gd-IgA1) laid the molecular basis of pathogenesis of IgAN. In addition, the involvement of mucosal and complement immune abnormalities in the pathogenesis of IgAN may also provide new directions for the diagnosis and treatment of IgAN.

Key words: IgA nephropathy, Galactose-deficient-IgA1, Mucosal immunity, Complement system, Pathogenesis

He Zhu, Daoling Xu, Changhua Liu, Gang Wu, Bo Gao, Guangyu Bi. Pathogenesis of IgA nephropathy: abnormal glycosylation of IgA1 and abnormal immunity[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2017, 06(04): 182-185.

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References 31

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