Lupus nephritis is a common and severe systemic lesion of systemic lupus erythematosus, with poor prognosis and tricky treatment. This article outlined the understanding of the etiology and pathogenesis of LN by traditional Chinese medicine (TCM), analyzed the syndrome differentiation stages and syndrome types of lupus nephritis, and proposed the strategy of TCM differentiation and treatment of lupus nephritis, namely syndrome differentiation plus disease differentiation for treatment by classification; treatment by stages, distinguishing the principal and secondary aspects as well as urgency and stagnation of diseases; placing emphasis on promoting blood circulation and removing blood stasis throughout the whole course; and persisting in the integration of Chinese and western medicines, and mutual complement of Chinese and western medicines, in order to provide ideas for the treatment of lupus nephritis with TCM.