To analyze the effect of tube-sealing method of single heparin saline or heparin saline plus antibiotics on the incapacity and infection of central venous catheter with cuff.

92 hemodialysis patients were selected, who were treated by the central venous catheter with cuff in the Department of Hemodialysis of Pengshan District People′s Hospital from January 2015 to March 2017. The patients were randomly divided into an experimental group and a control group according to the random number table method. The experimental group was given 45 mg/ml heparin saline plus 10 mg/ ml cefuroxime sodium while the control group was given 45 mg/ml heparin saline, for tube sealing. The two groups were compared in catheter infection rate, pathogen distribution, incidence of other complications, and catheter life. The Kaplan-Meier method was used to draw the catheter application curve, and the COX regression equation was used to analyze risk factors affecting use time of the catheter.

(1) The catheter infection rate was 2.17% in the experimental group and 17.39% in the control group, the difference of which was statistically significant (χ² = 4.434, P=0.035). (2) Staphylococcus aureus (40.00%), streptococcus (30.00%), and enterococci (20.00%) were the most common pathogens in the catheter-related infections. (3) Hemoglobin level and infection were the independent risk factors for the catheter survival, and the tube-sealing with antibiotics was an independent protective factor (P<0.05). (4) The incidence of complications other than infection was 10.86% (5/46) in the experimental group and 30.43% (14/46) in the control group, the difference of which was statistically significant (χ²=5.373, P=0.020). The median survival time of catheter was 52 (9 to 70) weeks and 58 (13 to 72) weeks in the control and experimental groups, respectively. The risk of catheter failure in the experimental group was significantly lower than that in the control group (HR=0.395, 95%CI 0.172- 0.965, P=0.048).

The tube-sealing method of heparin saline plus antibiotics could reduce the central venous catheter infection rate, reduce complications, and prolong the catheter survival, which is worthy of clinical promotion.