The role of the complements in the development of IgA nephropathy

doi:10.3877/cma.j.issn.2095-3216.2019.06.008

Abstract

Abstract:

IgA nephropathy is considered as an autoimmune disease, and characterized by the deposition of IgA in the mesangium of glomeruli. The pathogenesis of IgA nephropathy is not clear, but it has been confirmed that the complement system abnormally activated plays a critical role in the development of IgA nephropathy. Recent studies indicated that the complement activation in IgA nephropathy is mainly via the alternative pathway and lectin pathway. In this review, the contribution of the complement system to the IgA nephropathy was summarized.

Key words: IgA nephropathy, Complement system, Alternative pathway, Lectin pathway

Yan Zhang, Shuwei Duan, Guangyan Cai, Xiangmei Chen. The role of the complements in the development of IgA nephropathy[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2019, 08(06): 269-272.

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