Progress in research on IgA1 glycosylation abnormality and intervention by traditional Chinese medicine in IgA nephropathy

doi:10.3877/cma.j.issn.2095-3216.2018.03.010

Abstract

Abstract:

IgA nephropathy (IgAN) is the most common primary glomerulonephritis all over the world. The progression of the disease is different, and the clinical manifestations are diverse. About 10%-20% IgAN patients progress to end-stage renal failure within 10 years. Abnormal glycosylation of IgA1 is closely related to the pathogenesis of IgAN. Reducing abnormal glycosylation of IgA1 can effectively delay the progression of IgAN. Studying the pathogenesis of IgAN caused by abnormal glycosylation of IgA1 and the current status of treatment of IgAN by traditional Chinese medicine, is helpful for providing new ways and new ideas in diagnosis and treatment of IgAN.

Key words: IgA nephropathy, IgA1, Abnormal glycosylation, Pathogenesis, Traditional Chinese medicine

Chuan Yuan, Caihua Lie. Progress in research on IgA1 glycosylation abnormality and intervention by traditional Chinese medicine in IgA nephropathy[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2018, 07(03): 139-142.

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