Research progress on molecular mechanism of vascular calcification in chronic kidney disease

doi:10.3877/cma.j.issn.2095-3216.2021.04.009

Abstract

Abstract:

Disorders of mineral metabolism lead to osteogenic transdifferentiation of vascular smooth muscle cells (VSMC) in patients with chronic kidney disease (CKD), and the unbalanced regulation of promotion and inhibitory factors for calcification leads to vascular calcification. This review mainly focused on the vascular calcification mechanism in which the calcification-promoting factor Runt-related transcription factor 2 (Runx2) and T-cell death-associated gene 51 (TDAG51) were involved.

Key words: Vascular calcification, Vascular smooth muscle cell, Runx2, TDAG51

Han Yu, Baoxing Wang. Research progress on molecular mechanism of vascular calcification in chronic kidney disease[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2021, 10(04): 232-235.

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