Role and mechanism of autophagy in the pathogenesis and treatment of diabetic nephropathy

doi:10.3877/cma.j.issn.2095-3216.2021.06.010

Abstract

Abstract:

As a highly conservative lysosomal degradation pathway, autophagy degrades intracellular proteins and organelles to achieve the elimination and reuse of intracellular abnormal components. Base-line autophagy is necessary to maintain kidney homeostasis, while stress-induced autophagy widely contributes to the adaptive responses of renal cells. Mammalian target of rapamycin (mTOR), AMP-activated protein kinase (AMPK), silent information regulator 1 (SIRT1), and other nutrient-sensing signalling pathways, as well as intracellular stress signaling pathways such as oxidative stress, endoplasmic reticulum stress, and hypoxia stress, jointly regulate the onset and progression of autophagy under the condition of diabetic nephropathy. Studies have shown that autophagy was blocked in diabetic nephropathy, while autophagy-activating drugs including traditional Chinese herbal medicines showed good application prospects. This article summarized the latest research progress on the autophagy regulation signal pathways of kidney intrinsic cells under the condition of diabetic nephropathy, especially focusing on the role and mechanism of autophagy in the treatment of diabetic nephropathy with traditional Chinese medicine and its active ingredients.

Key words: Autophagy, Diabetic nephropathy, Pharmacotherapy, Traditional Chinese medicine

Shuyuan Wang, Zhen Yuan, Dekun Wang, Xiaoyue Tan. Role and mechanism of autophagy in the pathogenesis and treatment of diabetic nephropathy[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2021, 10(06): 347-351.

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URL: https://zhsbyjdzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-3216.2021.06.010

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References 44

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