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Chinese Journal of Kidney Disease Investigation(Electronic Edition) ›› 2022, Vol. 11 ›› Issue (01): 33-38. doi: 10.3877/cma.j.issn.2095-3216.2022.01.006

• Review • Previous Articles     Next Articles

Advances in the treatment of antineutrophil cytoplasmic antibody-associated vasculitis

Xin Wang1, Weiping Liu1,()   

  1. 1. Department of Nephrology, Qinhuangdao First Hospital Affiliated to Hebei Medical University, Qinhuangdao 066000, Hebei Province, China
  • Received:2021-04-21 Online:2022-02-28 Published:2022-03-23
  • Contact: Weiping Liu

Abstract:

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a life-threatening autoimmune disease characterized by necrotizing vasculitis of small and medium vessels. The current treatment strategy is high-dose glucocorticoid combined with immunosuppressant cyclophosphamide or rituximab, with a total remission rate of 70%-90%. However, the relapse rate after treatment is high, and the toxicity associated with glucocorticoid still determines the mortality rate and long-term quality of life. The main goal of AAV treatment is to prevent recurrence and minimize the occurrence of adverse events. Recent studies suggest that blockade of the bradykinin B1 receptor and inhibition of spleen tyrosine kinase may have a significant impact on the therapeutic outcome of AAV. This article reviewed the the latest research progress in the treatment of AAV to explore new treatment methods for reducing the recurrence and mortality rate of AAV and improving the quality of life of the patients.

Key words: Antineutrophil cytoplasmic antibody-associated vasculitis, Antineutrophil cytoplasmic antibody, Spleen tyrosine kinase, Bradykinin B1 receptor

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