Role of microRNA in acute kidney injury

doi:10.3877/cma.j.issn.2095-3216.2022.02.008

Abstract

Abstract:

Acute kidney injury (AKI) is a clinical syndrome caused by short-term rapid decline of renal function due to various causes, with high morbidity and mortality. In-depth study of the regulatory mechanism of AKI is very important for improving its prognosis. MicroRNAs (miRNAs) are endogenous short-chain non-coding RNAs that can regulate biological functions such as cellular proliferation, differentiation, metabolism, and apoptosis by affecting the post-transcriptional activity of target mRNAs. It has been found that miRNAs play important roles in various human diseases. Some miRNAs have pathogenic roles in AKI by promoting inflammation, apoptosis, and fibrosis, while others have renoprotective effects by inhibition of inflammation, apoptosis, and fibrosis as well as promotion of angiogenesis. Thus, miRNAs have not only emerged as novel biomarkers for AKI, but also held promise to be potential therapeutic targets. This review summarized the research progress on the role of miRNAs in AKI.

Key words: Acute kidney injury, MicroRNA, Messenger RNA

Xinyuan Feng, Xi Qiao. Role of microRNA in acute kidney injury[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2022, 11(02): 94-98.

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References 26

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