Role of Toll-like receptor in sepsis-induced acute kidney injury

doi:10.3877/cma.j.issn.2095-3216.2023.04.006

Abstract

Abstract:

Sepsis-induced acute kidney injury (SIAKI) is the most common type of acute kidney injury (AKI) in critically ill patients. Its pathogenesis is complex, in which excessive inflammation plays a key role. Toll-like receptors (TLRs) mediate signal pathways that can contribute to the transcription of pro-inflammatory cytokines, inflammation in the kidney, and lead to kidney injury. This article reviewed the biological characteristics of Toll-like receptors as well as their roles in SIAKI, aiming to provide ideas for exploring the therapeutic intervention targets of SIAKI.

Key words: Toll-like receptors, Sepsis, Acute kidney injury, Inflammation

Ruanxin Miao, Xi Qiao. Role of Toll-like receptor in sepsis-induced acute kidney injury[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2023, 12(04): 210-214.

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