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Chinese Journal of Kidney Disease Investigation(Electronic Edition) ›› 2025, Vol. 14 ›› Issue (01): 53-56. doi: 10.3877/cma.j.issn.2095-3216.2025.01.009

• Reviews • Previous Articles     Next Articles

Research progress on target antigen discovery and targeted therapy of membranous nephropathy

Xiaofang Shen1, Na Zhao1, Kejia Li1, Yuefei Xiao1,()   

  1. 1. Department of Nephrology, Aerospace Center Hospital,Beijing 100049, China
  • Received:2024-11-21 Online:2025-02-28 Published:2025-03-14
  • Contact: Yuefei Xiao

Abstract:

In recent years, significant advances in understanding the pathophysiological mechanisms of membranous nephropathy (MN) have revealed its underlying pathogenesis, primarily characterized by the interaction between autoantibodies and podocyte target antigens.Concurrently, the epidemiological features of MN have demonstrated regional variations and dynamic trends, offering novel insights for disease prevention and clinical management.This review systematically summarizes the latest progress in MN research, with a particular focus on the discovery of target antigens and innovative therapeutic approaches represented by targeted therapy,including anti-CD20 monoclonal antibodies, complement inhibitors, and proteasome inhibitors, in order to provide reference for the follow-up research and clinical diagnosis and treatment of membranous nephropathy.

Key words: Membranous nephropathy, Epidemiology, Target antigen, Targeted therapy

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