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Chinese Journal of Kidney Disease Investigation(Electronic Edition) ›› 2025, Vol. 14 ›› Issue (01): 48-52. doi: 10.3877/cma.j.issn.2095-3216.2025.01.008

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Research progress on point-of-care testing of early biomarkers for acute kidney injury

Xuwei He1, Yang Liu1, Qingli Cheng1, Qiangguo Ao1,()   

  1. 1. Department of Nephrology, Second Medical Center of Chinese PLA General Hospital,National Clinical Research Centre for Geriatric Diseases, Beijing 100853, China
  • Received:2024-08-08 Online:2025-02-28 Published:2025-03-14
  • Contact: Qiangguo Ao

Abstract:

For a long time, the diagnosis of acute kidney injury (AKI) has mainly relied on serum creatinine and estimated glomerular filtration rate, but the lag in detection often leads to missed optimal diagnosis and treatment opportunities in clinical practice.Contemporary nanotechnology and biomedical developments have brought hope for the early diagnosis of AKI.Point-of-care testing (POCT) for biomarkers such as kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, and microRNAs may make the diagnostic process of AKI faster, simpler, and of lower-cost.This article reviewed the significance of early biomarkers for AKI as well as the current status of their POCT research, and looked ahead to the future challenges and application prospects.

Key words: Acute kidney injury, Early biomarkers, Point-of-care testing

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