Abstract:
Objective To observe the clinical effect of Huangkui capsule combined with Jianpiyishen decoction on chronic kidney disease (CKD stage 3-4) patients with Pishengyangxu syndrome.
Methods 58 patients were randomly divided into treatment group (28 cases) and control group (30 cases). Both groups received the basic treatment of western medicine and the Jianpiyishen recipe (1 dose/day, decoction 100 ml/time, twice a day for 3 months). The treatment group was added with oral Huangkui capsule, 5 capsules/time, thrice a day for 3 months. Before treatment, and 3 months after the treatment, the following were detected: Hb, Alb, TC, TG, BUN, Cr, UA, eGFR, C-reactive protein (CRP), beta 2 microglobulin (β2-MG), serum superoxide dismutase (SOD), malondialdehyde (MDA), endothelin (ET), and nitric oxide (NO).
Results Compared with the control group, the treatment group showed significantly higher levels of Hb, Alb, NO, SOD, and eGFR (P<0.05) 3 months after the treatment, but showed significantly lower levels of TC, TG, BUN, Cr, UA, CRP, MDA, β2-MG, ET, and DBP (P<0.05), with all the differences being statistically significant. Both the primary and secondary manifestations of TCM Pishengyangxu syndrome disappeared, and the secondary sthenia syndrome manifestations were reduced.
Conclusion The effect of Huangkui capsule combined with Jianpiyishen formula on CKD (stage 3-4) patients with Pishengyangxu syndrome was better than that of Jianpiyishen recipe alone.
Key words:
Huangkui capsule,
Jianpiyishen,
Pishengyangxu
Chunhua Cao, Na Wang, Yaping Yu, Xudong Cong, Teng Ma, Dexi Peng, Ying Zhou, Xueqin Gu, Chengye Yuan. Effect of Huangkui capsule combined with Jianpiyishen decoction on CKD patients with Pishengyangxu syndrome[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2016, 05(06): 265-268.