Research progress on the mechanism of mitochondrial autophagy in regulating podocyte injury

doi:10.3877/cma.j.issn.2095-3216.2020.06.008

Abstract

Abstract:

Podocytes are the basic structural unit for maintaining glomerular function, and are of crucial significance for maintaining glomerular filtration. Cellular autophagy helps maintain podocyte integrity. Mitochondria, as the main organelle for cell energy supply, play an important role in regulating cell survival and death. As a kind of specific autophagy, mitochondrial autophagy can timely remove damaged and aging mitochondria in cells, thereby ensuring the number and function of normal mitochondria in cells, and playing an important role in cell growth and metabolism. Studies have shown that podocyte damage occurs in a variety of kidney diseases, accompanied by mitochondrial dysfunction or abnormal cell autophagy. Podocyte mitochondrial autophagy activity can regulate the homeostasis of podocytes through signal pathways of PINK1/Parkin and Nrf2/Keap1, etc. This article summarized the physiopathological manifestations of mitochondria and podocytes, and reviewed the possible mechanisms of the role of mitochondrial autophagy homeostasis in podocyte disease, which might be helpful in exploring new therapeutic pathways for podocyte disease.

Key words: Podocyte, Mitochondrial autophagy, Homeostasis, Regulation, Mechanism

Lifeng Wei, Xianwen Zhang, Lin Wang. Research progress on the mechanism of mitochondrial autophagy in regulating podocyte injury[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2020, 09(06): 275-278.

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