Progress of research on the role of ferroptosis in kidney diseases

doi:10.3877/cma.j.issn.2095-3216.2021.05.006

Abstract

Abstract:

Ferroptosis is a newly discovered mode of regulated cell death, which is caused by the imbalance of cellular redox system mediated by the accumulation of iron-mediated lipid peroxidation. The key mechanisms of ferroptosis pathway include cystine/glutamate antiporter, glutathione peroxidase 4, and polyunsaturated fatty acid biosynthesis pathways, etc. The inducers and inhibitors can promote or suppress ferroptosis by regulating the related targets, respectively. Existing researches suggested that ferroptosis was involved in the occurrence and development of a variety of kidney diseases. This article reviewed the latest progress of research on the role of ferroptosis in kidney diseases.

Key words: Ferroptosis, Iron metabolism, Kidney disease

Kaiqi Zhang, Jingkui Wu, Zhaohui Ni. Progress of research on the role of ferroptosis in kidney diseases[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2021, 10(05): 268-273.

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