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中华肾病研究电子杂志 ›› 2014, Vol. 03 ›› Issue (02) : 73 -76. doi: 10.3877/cma.j.issn.2095-3216.2014.02.004

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幽门螺杆菌感染与IgA 肾病的发生与发展
马欣1, 樊均明1,()   
  1. 1.646000 泸州医学院附属医院肾脏病科, 四川大学华西医院生物治疗国家重点实验室
  • 出版日期:2014-04-15
  • 通信作者: 樊均明
  • 基金资助:
    国家自然科学基金项目(81170667)四川省科技厅项目(2011JTD0014)

Helicobacter pylori infection and the development and progression of IgA nephropathy

Xin Ma1, Junming Fan1,()   

  1. 1.Department of Nephrology, Affiliated Hospital of Luzhou Medical College, Luzhou 646000;Sichuan University West China Hospital, State Key Laboratory of Biotherapy, Chengdu 610000, Sichuan Province, China
  • Published:2014-04-15
  • Corresponding author: Junming Fan
引用本文:

马欣, 樊均明. 幽门螺杆菌感染与IgA 肾病的发生与发展[J/OL]. 中华肾病研究电子杂志, 2014, 03(02): 73-76.

Xin Ma, Junming Fan. Helicobacter pylori infection and the development and progression of IgA nephropathy[J/OL]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2014, 03(02): 73-76.

IgA 肾病是全球范围内最为常见的原发性肾小球疾病,目前公认其是一种免疫介导性炎症疾病,但具体发病机制尚不清楚。 幽门螺杆菌(Hp)是一种定植于人类胃肠道的微需氧革兰阴性菌,幽门螺杆菌感染能引起急慢性的炎症免疫反应。 近年来研究发现Hp 感染与IgA 肾病之间存在一定的联系,Hp 可能是IgA 肾病的潜在致病原之一。 相关研究已成为目前学术界的热点。 该文结合国内外和四川大学生物治疗国家重点实验室团队的研究,就HP 感染与IgA 肾病的发生发展机制进行了论述。

IgA nephropathy is the most common primary glomerular disease worldwide which is recognized as a kind of immune-mediated inflammatory disease although its pathogenesis is not clear yet.Helicobacter pylori (Hp) is a kind of microaerobic gram-negative bacterium colonized in human gastrointestinal tract. Hp infection can cause acute or chronic immune inflammation. In recent years, it has been found that there is a certain relationship between Hp infection and IgA nephropathy, and that Hp is likely to be one of the potential pathogenic agents of IgA nephropathy, and related research has become a hot spot of academia. Whether Hp infection is associated with the development and progression of IgA nephropathy has become a hot spot of research. This review will discuss HP infection and pathological mechanism of IgA nephropathy, synthesizing domestic and international results including our own.

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