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中华肾病研究电子杂志 ›› 2017, Vol. 06 ›› Issue (04) : 173 -177. doi: 10.3877/cma.j.issn.2095-3216.2017.04.008

所属专题: 文献

论著

山西省维持性血液透析患者矿物质和骨异常控制情况的流行病学调查
李静1, 张楠楠2, 武晴文2, 程丽娟2, 张晓华2, 李荣山3, 王利华1,()   
  1. 1. 030001 山西医科大学第二医院肾内科;030001 山西省医疗质量控制中心血液净化质量控制部
    2. 030001 山西医科大学第二医院肾内科
    3. 030001 山西省人民医院 山西肾脏病研究所;030001 山西省医疗质量控制中心血液净化质量控制部
  • 收稿日期:2017-05-25 出版日期:2017-08-28
  • 通信作者: 王利华

Epidemiology investigation of mineral and bone disorder among maintenance hemodialysis patients in Shanxi Province

Jing Li1, Nannan Zhang2, Qingwen Wu2, Lijuan Cheng2, Xiaohua Zhang2, Rongshan Li3, Lihua Wang1,()   

  1. 1. Department of Nephrology, Second Hospital of Shanxi Medical University; Department of Blood Purification Quality Control, Center of Medical Quality Control of Shanxi Province; Taiyuan 030001, China
    2. Department of Nephrology, Second Hospital of Shanxi Medical University
    3. Shanxi Provincial People′s Hospital, Shanxi Institute of Kidney Disease; Department of Blood Purification Quality Control, Center of Medical Quality Control of Shanxi Province; Taiyuan 030001, China
  • Received:2017-05-25 Published:2017-08-28
  • Corresponding author: Lihua Wang
  • About author:
    Corresponding author: Wang Lihua, Email:
引用本文:

李静, 张楠楠, 武晴文, 程丽娟, 张晓华, 李荣山, 王利华. 山西省维持性血液透析患者矿物质和骨异常控制情况的流行病学调查[J/OL]. 中华肾病研究电子杂志, 2017, 06(04): 173-177.

Jing Li, Nannan Zhang, Qingwen Wu, Lijuan Cheng, Xiaohua Zhang, Rongshan Li, Lihua Wang. Epidemiology investigation of mineral and bone disorder among maintenance hemodialysis patients in Shanxi Province[J/OL]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2017, 06(04): 173-177.

目的

了解2012~2015年山西省维持性血液透析患者钙磷代谢异常的监测和控制情况,为实施血液透析持续质量改进提供数据支持。

方法

回顾性分析2012~2015年山西省所有开展血液净化治疗的医疗机构网上直报的维持性血液透析患者的临床资料。主要收集患者人口学资料和血钙、血磷、血全段甲状旁腺激素(iPTH)等指标。各种相关数据的采集通过全国血液净化病例登记系统完成。相关数据整理后用Excell2003建立数据库,进行数据分析。

结果

2012~2015年维持性血液透析患者血钙、血磷的检测率均偏低,血磷检测率近年来均在40%左右,血钙的检测率波动于35.7%~45.9%;血iPTH检测率更低,但有上升趋势,由8.9%上升至21.2%。以我国《慢性肾脏病矿物质与骨异常诊治指导》为标准,2012~2015年血液透析患者中各年度血磷达标者(1.13~1.78 mmol/L)分别占到41.6%、39.8%、40.7%和39.4%;性别分层显示血磷的控制情况女性明显好于男性;年龄分层分析显示年龄越小,血磷的控制越差,50岁以后的患者血磷控制明显改善,血磷的达标率也明显提高。2012~2015年血液透析患者中各年度血钙达标者(2.10~2.54 mmol/L)分别占到42.3%、49.8%、55.4%和56.4%,达标率逐年提高。性别分层显示血钙的控制情况女性略好于男性;年龄分层分析显示30~39岁,50~59岁及>70岁三个年龄段的患者血钙的达标率较高。2012~2015年山西省血液透析患者中,iPTH能控制在150~600 ng/L(达标)的患者分别占到58.3%、52.6%、51.2%和54.6%,各年度变化不明显。

结论

山西省维持性血透患者血磷、血钙及iPTH的检测率及达标率均偏低,血磷的达标率近年来无明显提高,血钙的达标率近年来逐步改善。

Objective

To observe the monitor and control situation of calcium and phosphorus metabolic disorder among maintenance hemodialysis (MHD) patients in Shanxi Province from 2012 to 2015, so as to provide data support for the continual improvement of hemodialysis.

Methods

Retrospective analysis of MHD patients′ clinical data directly reported online by all medical institutions carrying out blood purification therapy from 2012 to 2015 in Shanxi Province. The main collection includes patients′ demographic data, blood calcium, blood phosphorus, blood intact parathyroid hormone(iPTH), and so on. The collection of various related data was completed through the National Blood Purification Registration System. The data collected were then used in Excell2003 to establish a database for analysis.

Results

The detection rates of serum calcium and serum phosphorus in MHD patients were both lower from 2012 to 2015, and were 35.7%-45.9% and about 40% in recent years, respectively. The detection rate of iPTH was even lower, but has an upward trend, and has reached 21.2% from 8.9%. According to the guidelines for diagnosis and treatment of chronic kidney disease-mineral bone disease (CKD-MBD) of Chinese Society of Nephrology, during 2012-2015, the yearly rates of standard-reaching MHD patients in blood phosphorus (1.13-1.78 mmol/L) accounted for 41.6%, 39.8%, 40.7%, and 39.4%, respectively. The control of phosphorus in both female group and aged-over-50 group was better than in male group and in the aged-less-than-50 group. The yearly standard-reaching rate of calcium (2.10-2.54 mmol/L) among MHD patients from 2012 to 2015 was 42.3%, 49.8%, 55.4%, and 56.4%, respectively. The control of phosphorus was better in female group, aged 30-39 group, aged 50-59 group, and aged-over-70 group. The yearly rates of standard-reaching MHD patients with serum iPTH ranging 150-600 pg/ml were 58.3%, 52.6%, 51.2%, and 54.6%, respectively, from 2012 to 2015.

Conclusions

The rates of MHD patients receiving detection of calcium, phosphorus, and iPTH in Shanxi Province were low. The standard-reaching rate of blood phosphorus was not increased significantly in recent years, while the standard-reaching rate of blood calcium has been gradually improved in recent years.

表1 山西省血液透析患者血磷控制情况的年度变化[例(%),±s]
表2 性别分层的2015年山西省血液透析患者的血磷达标情况[例(%)]
表3 年龄分层的2015年山西省血液透析患者的血磷达标情况[例(%)]
表4 山西省血液透析患者血钙控制情况的年度变化[例(%),±s]
表5 性别分层的2015年山西省血液透析患者的血钙达标情况[例(%)]
表6 年龄分层的2015年山西省血液透析患者的血钙达标情况[例(%)]
表7 山西省血液透析患者血全段甲状旁腺激素控制情况的年度变化[例(%),±s]
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