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中华肾病研究电子杂志 ›› 2018, Vol. 07 ›› Issue (05) : 234 -237. doi: 10.3877/cma.j.issn.2095-3216.2018.05.010

所属专题: 文献

综述

利妥昔单抗在难治性肾病综合征中的应用现状
金众鑫1, 乔玉峰2,()   
  1. 1. 030001 山西医科大学
    2. 山西医科大学第二医院 山西省肾脏病研究所
  • 收稿日期:2018-04-12 出版日期:2018-10-28
  • 通信作者: 乔玉峰

Application status of rituximab in refractory nephrotic syndrome

Zhongxin Jin1, Yufeng Qiao2,()   

  1. 1. Shanxi Medical University; Taiyuan 030001, Shanxi Province, China
    2. Second Hospital of Shanxi Medical University, Kidney Disease Institute of Shanxi Province; Taiyuan 030001, Shanxi Province, China
  • Received:2018-04-12 Published:2018-10-28
  • Corresponding author: Yufeng Qiao
  • About author:
    Corresponding author: Qiao Yufeng, Email:
引用本文:

金众鑫, 乔玉峰. 利妥昔单抗在难治性肾病综合征中的应用现状[J]. 中华肾病研究电子杂志, 2018, 07(05): 234-237.

Zhongxin Jin, Yufeng Qiao. Application status of rituximab in refractory nephrotic syndrome[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2018, 07(05): 234-237.

原发性肾病综合征(idiopathic nephrotic syndrome, INS)是儿童及成人常见的肾小球疾病,糖皮质激素是INS治疗的基础用药。对于原发性难治性肾病综合征(idiopathic refractory nephrotic syndrome, IRNS)患者,多数需在糖皮质激素基础上联用其他免疫抑制剂或细胞毒类药物。近年来逐渐有学者利用利妥昔单抗(RTX)治疗IRNS并取得较好疗效,本文主要就IRNS的发病机制及RTX在不同病理类型中的应用情况做一综述。

Idiopathic nephrotic syndrome (INS) is a common glomerular disease in children and adults. Glucocorticoid is the basic drug for INS treatment. Most patients with idiopathic refractory nephrotic syndrome (IRNS) need to use other immunosuppressants or cytotoxic drugs on the basis of glucocorticoids. In recent years, some scholars have used rituximab (RTX) to treat IRNS and achieved good results. This article reviewed the pathogenesis of IRNS and the application of RTX in different pathological types.

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