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中华肾病研究电子杂志 ›› 2019, Vol. 08 ›› Issue (03) : 138 -141. doi: 10.3877/cma.j.issn.2095-3216.2019.03.008

所属专题: 文献

综述

微小RNA在糖尿病肾病中的作用机制研究进展
焦婷婷1, 韩秋霞2, 张冬3, 张有才4, 汤力3, 蔡广研3, 陈香美3, 朱晗玉3,()   
  1. 1. 100853 北京,解放军总医院第一医学中心肾脏病科、解放军肾脏病研究所、肾脏疾病国家重点实验室(2011DAV00088)、国家慢性肾病临床医学研究中心、肾脏疾病研究北京市重点实验室;454000 河南,新乡医学院焦作市人民医院肾内科
    2. 450052 河南,郑州大学第一附属医院肾脏病科、郑州大学肾脏病研究所、肾脏病重点实验室、河南省慢性病诊断与治疗重点实验室
    3. 100853 北京,解放军总医院第一医学中心肾脏病科、解放军肾脏病研究所、肾脏疾病国家重点实验室(2011DAV00088)、国家慢性肾病临床医学研究中心、肾脏疾病研究北京市重点实验室
    4. 454000 河南,新乡医学院焦作市人民医院肾内科
  • 收稿日期:2018-12-09 出版日期:2019-06-28
  • 通信作者: 朱晗玉
  • 基金资助:
    国家自然科学基金(61671479); 国家重点研发项目(2016YFC1305500); 中国人民解放军保健专项科研课题(15BJZ35)

Advances in research on the mechanism of microRNA in diabetic nephropathy

Tingting Jiao1, Qiuxia Han2, Dong Zhang3, Youcai Zhang4, Li Tang3, Guangyan Cai3, Xiangmei Chen3, Hanyu Zhu3,()   

  1. 1. Department of Nephrology, Chinese PLA General Hospital, First Medical Center of Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases, Beijing 100853; Department of Nephrology, Jiaozuo City People′s Hospital, Xinxiang Medical University, Jiaozuo 454000, Henan Province
    2. Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Research Institute of Nephrology of Zhengzhou University, Key Laboratory of Diagnosis and Treatment for Chronic Kidney Disease in Henan Province, Zhengzhou 450052, Henan Province; China
    3. Department of Nephrology, Chinese PLA General Hospital, First Medical Center of Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases, Beijing 100853
    4. Department of Nephrology, Jiaozuo City People′s Hospital, Xinxiang Medical University, Jiaozuo 454000, Henan Province
  • Received:2018-12-09 Published:2019-06-28
  • Corresponding author: Hanyu Zhu
  • About author:
    Corresponding author: Zhu Hanyu, Email:
引用本文:

焦婷婷, 韩秋霞, 张冬, 张有才, 汤力, 蔡广研, 陈香美, 朱晗玉. 微小RNA在糖尿病肾病中的作用机制研究进展[J]. 中华肾病研究电子杂志, 2019, 08(03): 138-141.

Tingting Jiao, Qiuxia Han, Dong Zhang, Youcai Zhang, Li Tang, Guangyan Cai, Xiangmei Chen, Hanyu Zhu. Advances in research on the mechanism of microRNA in diabetic nephropathy[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2019, 08(03): 138-141.

糖尿病肾病(DN)是糖尿病重要的微血管并发症之一,目前临床上缺乏可用于DN无创诊断的具有高度敏感性和特异性的诊断生物标志物。微小RNA(microRNA, miRNA)广泛存在于生物体中,在多种生理和病理过程均起关键作用,参与DN的发病机制。DN患者血液及尿液特异性miRNA的发现为寻找DN的诊断标志物提供了新的方向,将在DN的诊断及疾病严重程度评估中发挥重要的作用。

Diabetic nephropathy (DN) is one of the important microvascular complications of diabetes. Currently, there is a lack of highly sensitive and specific biodiagnostic markers for non-invasive diagnosis of DN. MicroRNAs (miRNAs) are widely present in organisms and play a key role in a variety of physiological and pathological processes, participating in the pathogenesis of DN. The discovery of blood- and urine-specific miRNAs in patients with DN provides a new direction for the search for diagnostic markers of DN, and will play an important role in the diagnosis of DN and the assessment of disease severity.

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