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中华肾病研究电子杂志 ›› 2021, Vol. 10 ›› Issue (01) : 44 -46. doi: 10.3877/cma.j.issn.2095-3216.2021.01.009

所属专题: 文献

综述

脂肪酸结合蛋白4在肾脏疾病中的研究进展
杜晓艳1, 黄蓉双2, 马良3,(), 付平2   
  1. 1. 610041 成都,四川大学华西医院临床药学部/药剂科
    2. 610041 成都,四川大学华西医院肾内科
    3. 610041 成都,四川大学华西医院临床药学部/药剂科;610041 成都,四川大学华西医院肾内科
  • 收稿日期:2020-10-06 出版日期:2021-02-28
  • 通信作者: 马良
  • 基金资助:
    国家重点研发计划"重大慢性非传染性疾病防控研究"项目(2016YFC1305403)

Research progress of fatty acid-binding protein 4 in kidney diseases

Xiaoyan Du1, Rongshuang Huang2, Liang Ma3,(), Ping Fu2   

  1. 1. Department of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
    2. Department of Nephrology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
    3. Department of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China; Department of Nephrology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2020-10-06 Published:2021-02-28
  • Corresponding author: Liang Ma
引用本文:

杜晓艳, 黄蓉双, 马良, 付平. 脂肪酸结合蛋白4在肾脏疾病中的研究进展[J/OL]. 中华肾病研究电子杂志, 2021, 10(01): 44-46.

Xiaoyan Du, Rongshuang Huang, Liang Ma, Ping Fu. Research progress of fatty acid-binding protein 4 in kidney diseases[J/OL]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2021, 10(01): 44-46.

脂肪酸结合蛋白4 (FABP4)在机体能量代谢和炎症反应中起重要调控作用,与糖尿病、肥胖、动脉粥样硬化、肿瘤等密切相关。大量研究证实FABP4参与多种肾脏疾病的病理生理过程,有望成为肾脏病诊断的生物标志物和潜在药物靶点。本文结合笔者课题组研究工作,综述近年来FABP4在肾脏疾病中的研究进展。

Fatty acid-binding protein 4 (FABP4) plays an important regulatory role in the body′s energy metabolism and inflammatory response, and is closely related to diabetes, obesity, atherosclerosis, and tumors. Considerable studies have confirmed that FABP4 is involved in the pathophysiological process of a variety of kidney diseases, and is expected to become a potential drug target as well as a biomarker for the diagnosis of kidney diseases. This article reviewed the research progress of FABP4 in renal diseases in recent years, combining the research work of the authors′ group.

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