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中华肾病研究电子杂志 ›› 2021, Vol. 10 ›› Issue (01) : 40 -43. doi: 10.3877/cma.j.issn.2095-3216.2021.01.008

所属专题: 文献

综述

急性肾损伤后脑损伤的研究进展
宫铭1, 陈香美1,()   
  1. 1. 100853 北京,解放军总医院第一医学中心肾脏病科、解放军肾脏病研究所、肾脏疾病国家重点实验室、国家慢性肾病临床医学研究中心、肾脏疾病研究北京市重点实验室
  • 收稿日期:2020-04-02 出版日期:2021-02-28
  • 通信作者: 陈香美
  • 基金资助:
    "十三五"军队后勤科研项目(BLB19J009)

Research progress of brain injury after acute kidney injury

Ming Gong1, Xiangmei Chen1,()   

  1. 1. Department of Nephrology, First Medical Center of Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases, Beijing 100853, China
  • Received:2020-04-02 Published:2021-02-28
  • Corresponding author: Xiangmei Chen
引用本文:

宫铭, 陈香美. 急性肾损伤后脑损伤的研究进展[J]. 中华肾病研究电子杂志, 2021, 10(01): 40-43.

Ming Gong, Xiangmei Chen. Research progress of brain injury after acute kidney injury[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2021, 10(01): 40-43.

越来越多的证据表明急性肾损伤(Acute Kidney Injury, AKI)除了造成肾脏损伤外,也会使其它远隔器官受累,甚至于出现多器官功能障碍,这是导致AKI高死亡率的重要原因之一。其中,AKI导致的中枢神经系统损伤不容忽视,AKI危重患者的高死亡率和长住院时间都与神经系统并发症密切相关。因此,AKI造成的脑损伤是目前备受关注的研究热点,本文就AKI导致脑损伤的基础和临床研究进展作一综述。

More and more evidences show that acute kidney injury (AKI) not only causes kidney damage, but also affects other distant organs, and even triggers multiple organ dysfunction, which is an important reason for the high mortality of AKI. Among them, the central nervous system damage caused by AKI cannot be ignored. The high mortality and long hospital stay of critically ill patients with AKI are closely related to neurological complications. Therefore, the brain damage caused by AKI is a research hotspot at present. This article summarized the basic and clinical research progress of brain damage caused by AKI.

图1 AKI致脑损伤主要病理生理学机制
[1]
Hoste EAJ, Kellum JA, Selby NM, et al. Global epidemiology and outcomes of acute kidney injury [J]. Nat Rev Nephrol, 2018, 14(10): 607-625.
[2]
蔡广研,陈香美. 战创伤及特殊作业环境相关急性肾损伤的防治[J]. 解放军医学杂志,2019, 44(7): 546-549.
[3]
Susantitaphong P, Cruz DN, Cerda J, et al. World incidence of AKI: a meta-analysis [J]. Clin J Am Soc Nephrol, 2013, 8(9): 1482-1493.
[4]
Tanaka S, Okusa MD. Crosstalk between the nervous system and the kidney [J]. Kidney Int, 2020, 97(3): 466-476.
[5]
Lee SA, Cozzi M, Bush EL, et al. Distant organ dysfunction in acute kidney injury: a review [J]. Am J Kidney Dis, 2018, 72(6): 846-856.
[6]
Shiao C, Wu P, Huang T, et al. Long-term remote organ consequences following acute kidney injury [J]. Crit Care, 2015, 19: 438.
[7]
冯哲,陈香美. 急性肾损伤导致远隔器官功能障碍的机制[J/CD]. 中华肾病研究电子杂志,2015, 4 (3): 155-159.
[8]
Lu R, Kiernan MC, Murray A, et al. Kidney-brain crosstalk in the acute and chronic setting [J]. Nat Rev Nephrol, 2015, 11(12): 707-719.
[9]
Kao C, Yang W, Fang J, et al. Remote organ failure in acute kidney injury [J]. J Formos Med Assoc, 2019, 118(5): 859-866.
[10]
Firouzjaei MA, Haghani M, Shid Moosavi SM. Renal ischemia/reperfusion induced learning and memory deficit in the rat: Insights into underlying molecular and cellular mechanisms [J]. Brain Res, 2019, 1719: 263-273.
[11]
Liu M, Liang Y, Chigurupati S, et al. Acute kidney injury leads to inflammation and functional changes in the brain [J]. J Am Soc Nephrol, 2008, 19(7): 1360-1370.
[12]
Chou A, Lee C, Chen C, et al. Hippocampal transcriptional dysregulation after renal ischemia and reperfusion [J]. Brain Res, 2014, 1582: 197-210.
[13]
Gupta A, Kumar D, Puri S, et al. Neuroimmune mechanisms in signaling of pain during acute kidney injury (AKI) [J]. Front Med (Lausanne), 2020, 7: 424.
[14]
Anderson S, Eldadah B, Halter JB, et al. Acute kidney injury in older adults [J]. J Am Soc Nephrol, 2011, 22(1): 28-38.
[15]
Kumar V. Toll-like receptors in the pathogenesis of neuroinflammation [J]. J Neuroimmunol, 2019, 332: 16-30.
[16]
Salama M, Farrag SM, Abulasrar SA, et al. Up-regulation of TLR-4 in the brain after ischemic kidney-induced encephalopathy in the rat [J]. CNS Neurol Disord Drug Targets, 2013, 12(5): 583-586.
[17]
达静静,查艳. 慢性肾脏病营养代谢中的脑-肾对话[J]. 中国实用内科杂志,2019, 39 (11): 937-940.
[18]
Sies H. Oxidative stress: a concept in redox biology and medicine [J]. Redox Biol, 2015, 4: 180-183.
[19]
Malek M. Brain consequences of acute kidney injury: focusing on the hippocampus [J]. Kidney Res Clin Pract, 2018, 37(4): 315-322.
[20]
Kovalcíková A, Gyurászová M, Vavrincová-Yaghi D, et al. Oxidative stress in the brain caused by acute kidney injury [J]. Metab Brain Dis, 2018, 33(3): 961-967.
[21]
Yu F, Liang H, Xin S. Renal ischemia reperfusion cause brain hippocampus oxidative damage and inhibition effect [J]. Afr J Tradit Complement Altern Med, 2016, 13(5): 61-66.
[22]
Sharifi F, Reisi P, Malek M. Angiotensin 1 receptor antagonist attenuates acute kidney injury-induced cognitive impairment and synaptic plasticity via modulating hippocampal oxidative stress [J]. Life Sci, 2019, 234: 116775.
[23]
Zhao L, Cao X, Li L, et al. Acute kidney injury sensitizes the brain vasculature to Ang II (angiotensin II) constriction via FGFBP1 (fibroblast growth factor binding protein 1) [J]. Hypertension, 2020, 76 (6): 1924-1934.
[24]
Cheng CF, Ku HC, Lin H. PGC-1alpha as a pivotal factor in lipid and metabolic regulation [J]. Int J Mol Sci, 2018, 19(11): 3447.
[25]
Yip HK, Chen KH, Dubey NK, et al. Cerebro- and renoprotective activities through platelet-derived biomaterials against cerebrorenal syndrome in rat model [J]. Biomaterials, 2019, 214: 119227.
[26]
Wu VC, Wu PC, Wu CH, et al. The impact of acute kidney injury on the long-term risk of stroke [J]. J Am Heart Assoc, 2014, 3(4): e000933.
[27]
Tsai H, Yen R, Lin C, et al. Increased risk of dementia in patients hospitalized with acute kidney injury: A nationwide population-based cohort study [J]. PLoS One, 2017, 12(2): e0171671.
[28]
Guerra C, Linde-Zwirble WT, Wunsch H. Risk factors for dementia after critical illness in elderly medicare beneficiaries [J]. Crit Care, 2012, 16(6): R233.
[29]
Conroy AL, Opoka RO, Bangirana P, et al. Acute kidney injury is associated with impaired cognition and chronic kidney disease in a prospective cohort of children with severe malaria [J]. BMC Med, 2019, 17(1): 98.
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