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中华肾病研究电子杂志 ›› 2023, Vol. 12 ›› Issue (05) : 287 -290. doi: 10.3877/cma.j.issn.2095-3216.2023.05.009

综述

抗病毒药物和急性肾损伤
李金璞, 饶向荣()   
  1. 100053 北京,中国中医科学院广安门医院肾病科
  • 收稿日期:2022-09-23 出版日期:2023-10-28
  • 通信作者: 饶向荣

Antiviral drugs and acute kidney injury

Jinpu Li, Xiangrong Rao()   

  1. Department of Nephrology, Guang′anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
  • Received:2022-09-23 Published:2023-10-28
  • Corresponding author: Xiangrong Rao
引用本文:

李金璞, 饶向荣. 抗病毒药物和急性肾损伤[J]. 中华肾病研究电子杂志, 2023, 12(05): 287-290.

Jinpu Li, Xiangrong Rao. Antiviral drugs and acute kidney injury[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2023, 12(05): 287-290.

抗病毒药物是临床常用药,可通过多种机制导致急性肾损伤,包括肾脏低灌注、直接肾小管毒性、晶体肾病和血栓性微血管病等。新型冠状病毒感染(COVID-19)使抗病毒药物相关肾损伤获得了广泛的临床关注。本文回顾抗病毒药物在COVID-19治疗中的表现及其对肾脏的影响,总结了抗病毒药物相关急性肾损伤的临床表现和病理机制。

Antiviral drugs are commonly used in clinical practice, and may lead to acute kidney injury through a variety of mechanisms, including renal hypoperfusion, direct renal tubular toxicity, crystal nephropathy, and thrombotic microangiopathy, etc. The pandemic of COVID-19 has brought antiviral drug-associated kidney injury to extensive clinical focus. This article reviewed the performances of antiviral drugs in COVID-19 treatment and their effect on the kidney, and summarized the clinical manifestations and pathological mechanisms of antiviral drug-associated acute kidney injury.

表1 新型冠状病毒感染治疗中的抗病毒药相关急性肾损伤
表2 新型冠状病毒感染抗病毒药联用或合用他药相关急性肾损伤
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