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中华肾病研究电子杂志 ›› 2023, Vol. 12 ›› Issue (05) : 282 -286. doi: 10.3877/cma.j.issn.2095-3216.2023.05.008

综述

膜性肾病靶抗原的研究进展
代叶梅, 苏晓乐, 王利华()   
  1. 030000 太原,山西医科大学第二医院肾内科
  • 收稿日期:2022-05-30 出版日期:2023-10-28
  • 通信作者: 王利华

Research progress on target antigens of membranous nephropathy

Yemei Dai, Xiaole Su, Lihua Wang()   

  1. Department of Nephrology, Second Hospital of Shanxi Medical University, Taiyuan 030000, Shanxi Province, China
  • Received:2022-05-30 Published:2023-10-28
  • Corresponding author: Lihua Wang
引用本文:

代叶梅, 苏晓乐, 王利华. 膜性肾病靶抗原的研究进展[J/OL]. 中华肾病研究电子杂志, 2023, 12(05): 282-286.

Yemei Dai, Xiaole Su, Lihua Wang. Research progress on target antigens of membranous nephropathy[J/OL]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2023, 12(05): 282-286.

膜性肾病(MN)是由抗体介导的一种特异性自身免疫性疾病,其发病机制主要是自身抗体结合靶抗原后激活补体,导致肾小球滤过屏障损伤和蛋白尿。现已发现了MN靶抗原包括M型磷脂酶A2受体(PLA2R)、1型血小板反应蛋白7A域(THSD7A)、外泌素1/2复合物(EXT1/2)、神经表皮生长因子样蛋白1(NELL-1)、丝氨酸蛋白酶高温需求因子A1(HTRA1)、臂板蛋白3B(Sema3B)、神经细胞黏附分子1(NCAM1)、原钙粘蛋白7(PCDH7)、转化生长因子β受体3(TGFBR3)和接触蛋白1(CNTN1)等。本文对这些靶抗原的研究进展进行综述,为MN临床诊治提供参考。

Membrane nephropathy (MN) is a specific autoimmune disease mediated by antibodies. Its pathogenesis is mainly the activation of complements by the binding of autoantibodies to target antigens, leading to damage to the glomerular filtration barrier and proteinuria. In recent years, multiple target antigens of MN have been discovered, including M-type phospholipase A2 receptor (PLA2R), thrombospondin type 1 domain-containing 7A (THSD7A), exostosin 1/2 complex (EXT1/2), neural epidermal growth factor-like 1 protein (NELL-1), high temperature requirement factor A1 (HTRA1), semaphorin 3B (Sema3B), neural cell adhesion molecule 1 (NCAM1), procalcadherin 7 (PCDH7), transforming growth factor β receptor 3 (TGFBR3), and contactin 1 (CNTN1), etc. Research on these target antigens is of great significance in the diagnosis and treatment monitoring of MN. This article reviewed the research progress on target antigens in MN so as to provide reference for its clinical diagnosis and treatment.

表1 MN相关靶抗原的特点
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