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中华肾病研究电子杂志 ›› 2023, Vol. 12 ›› Issue (04) : 215 -219. doi: 10.3877/cma.j.issn.2095-3216.2023.04.007

综述

肠道菌群及其代谢产物在急性肾损伤中的作用研究进展
李娜, 朱国贞()   
  1. 030001 太原,山西医科大学第二医院肾内科
  • 收稿日期:2022-09-07 出版日期:2023-08-28
  • 通信作者: 朱国贞
  • 基金资助:
    山西省自然科学研究面上项目(202103021224420)

Progress of research on the roles of gut microbiota and its metabolites in acute kidney injury

Na Li, Guozhen Zhu()   

  1. Department of Nephrology, Second Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
  • Received:2022-09-07 Published:2023-08-28
  • Corresponding author: Guozhen Zhu
引用本文:

李娜, 朱国贞. 肠道菌群及其代谢产物在急性肾损伤中的作用研究进展[J]. 中华肾病研究电子杂志, 2023, 12(04): 215-219.

Na Li, Guozhen Zhu. Progress of research on the roles of gut microbiota and its metabolites in acute kidney injury[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2023, 12(04): 215-219.

急性肾损伤(AKI)导致肠道菌群失调,而失调的肠道菌群会加重AKI进展,从而形成肠-肾恶性循环。肠道益生菌及其代谢产物可能通过阻断肠-肾恶性循环而具有抑制AKI进展作用,有可能会成为AKI的新疗法。本文就肠道菌群在AKI中作用的研究进展作一综述。

Studies have found that AKI could lead to gut microbiota imbalance, while the imbalance of gut microbiota could aggravate the progression of AKI, forming a gut-kidney vicious cycle. Probiotics and their metabolites might inhibit the progression of AKI by blocking the gut-kidney vicious cycle, which may become a new therapy for AKI. This article reviewed the progress of research on the role of gut microbiota in AKI.

图1 急性肾损伤对肠道菌群的影响示意图
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