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中华肾病研究电子杂志 ›› 2022, Vol. 11 ›› Issue (03) : 148 -151. doi: 10.3877/cma.j.issn.2095-3216.2022.03.006

综述

肠道菌群对急性肾损伤的影响
朱丽君1, 乔晞1,()   
  1. 1. 030001 太原,山西医科大学第二医院、山西省肾脏病研究所、山西医科大学肾脏病研究所
  • 收稿日期:2021-12-23 出版日期:2022-06-28
  • 通信作者: 乔晞
  • 基金资助:
    国家自然科学基金面上项目(81970643); 山西省回国留学人员科研资助项目(2020-186); 山西省留学回国人员科技活动择优资助项目(2017-29)

Impact of gut microbiota on acute kidney injury

Lijun Zhu1, Xi Qiao1,()   

  1. 1. Department of Nephrology, Second Hospital of Shanxi Medical University, Shanxi Provincial Institute for Kidney Disease, Kidney Disease Institute of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
  • Received:2021-12-23 Published:2022-06-28
  • Corresponding author: Xi Qiao
引用本文:

朱丽君, 乔晞. 肠道菌群对急性肾损伤的影响[J/OL]. 中华肾病研究电子杂志, 2022, 11(03): 148-151.

Lijun Zhu, Xi Qiao. Impact of gut microbiota on acute kidney injury[J/OL]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2022, 11(03): 148-151.

急性肾损伤(AKI)是一个全球性的健康问题。一些证据表明,肠道菌群在AKI中起到非常重要的作用。在动物中,宿主AKI和肠道菌群之间存在相互影响的关系。肠道菌群可以显著影响AKI的预后,AKI后也可以导致肠道菌群的变化,两者的相互作用被称为"肠-肾"轴。本文对肠道菌群在AKI中的作用、肠道菌群影响AKI的潜在分子机制,以及肠道菌群在AKI治疗中的应用前景做一综述。

Acute kidney injury (AKI) is a global health problem. Some evidence suggests that the gut microbiota plays a very important role in AKI. In animals, there is a reciprocal relationship between the host AKI and the gut microbiota. The gut microbiota can significantly affect the prognosis of AKI, and AKI can also lead to changes of the gut microbiota. The interaction between them is called the "gut-kidney" axis. This article reviewed the role of gut microbiota in AKI, the potential molecular mechanism of gut microbiota affecting AKI, and the application prospect of gut microbiota in AKI treatment.

图1 肠道菌群失调参与AKI的机制注:SCFAs:短链脂肪酸;TMAO:trimethylamine-N-oxide,三甲胺-N-氧化物;IS:indoxyl sulfate,吲哚硫酸盐;p-CS:p-cresyl sulfate,对甲酚硫酸盐;GPR41:G protein-coupled receptor 41, G蛋白偶联受体41;GPR43:G protein-coupled receptor 43, G蛋白偶联受体43;GPR109A:G protein-coupled receptor 109A, G蛋白偶联受体109A;Olfr78:Olfactory receptor 78,嗅觉受体78
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