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中华肾病研究电子杂志 ›› 2026, Vol. 15 ›› Issue (02) : 100 -107. doi: 10.3877/cma.j.issn.2095-3216.2026.02.006

综述

肾脏缺血再灌注损伤中铁死亡的分子机制及治疗新视角
李旭, 乔玉峰()   
  1. 030012 太原,山西医科大学附属山西省人民医院肾内科
  • 收稿日期:2025-04-02 出版日期:2026-04-28
  • 通信作者: 乔玉峰

Molecular mechanisms of ferroptosis in renal ischemia-reperfusion injury and novel therapeutic perspectives

Xu Li, Yufeng Qiao()   

  1. Department of Nephrology, Shanxi Provincial People′s Hospital Affiliated to Shanxi Medical University, Taiyuan 030012, Shanxi Province, China
  • Received:2025-04-02 Published:2026-04-28
  • Corresponding author: Yufeng Qiao
引用本文:

李旭, 乔玉峰. 肾脏缺血再灌注损伤中铁死亡的分子机制及治疗新视角[J/OL]. 中华肾病研究电子杂志, 2026, 15(02): 100-107.

Xu Li, Yufeng Qiao. Molecular mechanisms of ferroptosis in renal ischemia-reperfusion injury and novel therapeutic perspectives[J/OL]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2026, 15(02): 100-107.

肾脏缺血再灌注损伤多呈不可逆性,目前临床仍缺乏有效治疗手段。近年研究表明铁死亡是介导肾脏缺血再灌注损伤中肾小管上皮细胞死亡的重要机制,已成为该领域的研究热点。本文综述了肾脏缺血再灌注损伤中铁死亡的分子机制及新型靶点研究进展,并探讨靶向铁死亡的药物开发现状与前景。

Renal ischemia-reperfusion injury is often irreversible, and effective clinical treatments remain scarce. Recent studies have demonstrated that ferroptosis is a critical mechanism mediating renal tubular epithelial cell death in renal ischemia-reperfusion injury, making it a prominent research hotspot. This review summarizes the molecular mechanisms of ferroptosis and the progress in identifying novel targets in renal ischemia-reperfusion injury, and also discusses the current status and future prospects of developing drugs that target ferroptosis.

表1 铁死亡靶点在肾脏缺血再灌注损伤中的发现
表2 铁死亡抑制剂在肾脏缺血再灌注损伤中的作用
表3 铁死亡相关药物在肾脏缺血再灌注损伤中的作用
表4 纳米载体技术在肾脏缺血再灌注损伤中的发现
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