MicroRNA and their role in kidney disease

doi:10.3877/cma.j.issn.2095-3216.2012.02.012

Abstract

Abstract:

microRNAs (miRNA) are a group of short non-coding RNA, which could inhibit target gene expression via blocking the target gene protein translation or inducing mRNA degradation. Currently, miRNA has quickly become the new direction of the kidney disease-related biomedical research. miRNA has been shown to participate in the development and prognosis of the pathogenesis of diabetic nephropathy, IgA nephropathy and other kidney diseases. Therefore, miRNA may be a new target for the treatment of these diseases in the future. This review is to summarize miRNA in renal physiology and pathology and the participation process and the role of research in various kidney diseases, and to provide references for diagnosis and treatment of kidney disease in the future.

Key words: microRNAs, Diabetic nephropathy, Polycystic kidney disease, IgA nephropathy, Acute kidney injury

Da-peng CHEN, Xiang-mei CHEN. MicroRNA and their role in kidney disease[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2012, 01(02): 119-124.

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miRNA	已被证实的靶基因	相关的肾脏疾病
miR-15a^[26]	Cdc25A	细胞周期过快导致的多囊肾病
miR-17^[49]	PKD2	细胞增殖，多囊肾病
miR-17-92^[50]	PTEN	肾小球硬化，系膜细胞肥大，蛋白尿
miR-21^[51]	PTEN	系膜细胞增殖
miR-30^[11-13,52]	CTGF	肾脏固有高表达miRNA与肾小球发育成熟有关
miR-200a,miR-200b,miR-141, miR-429,miR-205,miR-192^{[17-18,28-30,53-54]}	ZEB1 ZEB2	糖尿病肾病，IgA肾病，糖尿病肾病，肾脏纤维化与肾肿瘤
miR-216a,miR-217^[18]	PTEN	糖尿病肾病肾小球纤维化
miR-377^[55]	PAK1 MnSOD	糖尿病肾病系膜细胞增殖
miR-29a^[20]	COL4A1 COL4A2	糖尿病肾病

miRNA	已被证实的靶基因	相关的肾脏疾病
miR-15a^[26]	Cdc25A	细胞周期过快导致的多囊肾病
miR-17^[49]	PKD2	细胞增殖，多囊肾病
miR-17-92^[50]	PTEN	肾小球硬化，系膜细胞肥大，蛋白尿
miR-21^[51]	PTEN	系膜细胞增殖
miR-30^[11-13,52]	CTGF	肾脏固有高表达miRNA与肾小球发育成熟有关
miR-200a,miR-200b,miR-141, miR-429,miR-205,miR-192^{[17-18,28-30,53-54]}	ZEB1 ZEB2	糖尿病肾病，IgA肾病，糖尿病肾病，肾脏纤维化与肾肿瘤
miR-216a,miR-217^[18]	PTEN	糖尿病肾病肾小球纤维化
miR-377^[55]	PAK1 MnSOD	糖尿病肾病系膜细胞增殖
miR-29a^[20]	COL4A1 COL4A2	糖尿病肾病

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