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Chinese Journal of Kidney Disease Investigation(Electronic Edition) ›› 2014, Vol. 03 ›› Issue (04): 200-203. doi: 10.3877/cma.j.issn.2095-3216.2014.04.006

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Reasonable application of tacrolimus in renal diseases

Niansong Wang1,(), Dingkun Gui1, Junhui Li1   

  1. 1.Department of Nephrology, Sixth People's Hospital Affiliated to Shanghai Jiaotong University. Shanghai 200233, China
  • Online:2014-08-15 Published:2024-11-28
  • Contact: Niansong Wang

Abstract:

Tacrolimus, a novel immunosuppressant, can protect podocytes and reduce urinary protein. Recent studies show that tacrolimus has higher remission rate than cyclophosphamide (CTX) in treatment of idiopathic membranous nephropathy (IMN). And tacrolimus therapy can effectively and safety treat minimal change nephropathy (MCD). Tacrolimus can also reduce proteinuria in both refractory focal segmental glomerulosclerosis (FSGS) and refractory lupus nephritis (LN) with good clinical remission rate and tolerability. Besides, tacrolimus has better efficacy and safety in treatment of steroid-resistant children nephrotic syndrome (NS). KDIGO (Kidney Disease: Improving Global Outcomes) guidelines recommend tacrolimus to be used in treatment of IMN, MCD, FSGS, LN, and children NS. However, there are some side effects of tacrolimus, including immunosuppression and infection, tremor, insomnia, elevated serum creatinine, high blood glucose, high blood pressure, and so on. Therefore, we should pay attention to the reasonable, effective and safe application of tacrolimus in treatment of kidney diseases.

Key words: Tacrolimus, Chronic kidney disease

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