Reflections on the nephrotoxicity of Chinese herbs genus Aristolochia

doi:10.3877/cma.j.issn.2095-3216.2018.01.006

Abstract

Abstract:

Recently, Translational Medicine reported on the toxicities of aristolochic acid (AA) in its cover story, which once again caused the public to question the safety of genus Aristolochia herbs. This article started with the case report of "Chinese herbal nephropathy", and combed the discovery process of "AA nephropathy" and "Balkan endemic nephropathy" as well as the relationship among the three. At the same time, the mechanism of nephrotoxicity was analyzed based on the following aspects: clinical in vivo studies have confirmed that AA caused renal tubular epithelial cell damage; animal in vivo and in vitro studies have shown that AA interfered with microRNA; and endoplasmic reticulum stress or oxidative stress led to renal cell apoptosis and AA-mediated inflammatory injury, etc, which introduced the enlightenment from the AA nephrotoxicity events, in order to expect further strengthening supervision of Chinese herbs containing AA at all levels of drug regulatory authorities of our country, and carrying out new clinical epidemiological studies to update the incidences of AA hepatotoxicity and nephrotoxicity caused by the Chinese herbal medicine genus Aristolochia in China.

Key words: Aristolochic acid, Aristolochic acid nephropathy, Genus Aristolochia, Nephrotoxicity

Xiaoqin Wang, Wencheng Xu. Reflections on the nephrotoxicity of Chinese herbs genus Aristolochia[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2018, 07(01): 23-27.

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References 40

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药材名	属名	拉丁名	2015版《中国药典》
防己(别名：汉防己、粉防己)	千金藤属	Stephania tetrandra S. Moore	收载
木防己	木防己属	Cocculus trilobus (L.) DC	未收载
广防己	马兜铃属	Aristolochia fangchi Y．C. Wu et Hwang	未收载
汉中防己	马兜铃属	Aristolochia heterophylla Hemsl	未收载

药材名	属名	拉丁名	2015版《中国药典》
防己(别名：汉防己、粉防己)	千金藤属	Stephania tetrandra S. Moore	收载
木防己	木防己属	Cocculus trilobus (L.) DC	未收载
广防己	马兜铃属	Aristolochia fangchi Y．C. Wu et Hwang	未收载
汉中防己	马兜铃属	Aristolochia heterophylla Hemsl	未收载

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