NADPH oxidase and renal interstitial fibrosis

doi:10.3877/cma.j.issn.2095-3216.2018.01.010

Abstract

Abstract:

Oxidative stress plays an important role in the development and progression of renal interstitial fibrosis. Reactive oxygen species (ROS) are the most important signal molecules in the process of oxidative stress. ROS produced by the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) pathway is the major source of ROS during renal interstitial fibrosis. NOX4 is the major subtype of NOX in the kidney, and NOX1, NOX2, and NOX5 are also expressed in the kidney. The ROS produced by NOX mediates the development and progression of renal interstitial fibrosis through various pathways. This article reviewed the progress of research on roles of different subtypes of NOX in renal interstitial fibrosis.

Key words: Nicotinamide adenine dinucleotide phosphate oxidase, Renal interstitial fibrosis, Reactive oxygen species

Li Zhang, Xi Qiao. NADPH oxidase and renal interstitial fibrosis[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2018, 07(01): 44-46.

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