Progress of research on inhibition of Wnt/β-catenin signaling pathway to delay renal interstitial fibrosis

doi:10.3877/cma.j.issn.2095-3216.2023.04.009

Abstract

Abstract:

Renal interstitial fibrosis is an important pathological basis for the progression of chronic kidney disease. Delaying the process of renal interstitial fibrosis may inhibit the progression of chronic kidney disease. In animal models of renal interstitial fibrosis, the use of Wnt inhibitors could interfere with signal transduction of Wnt/β-catenin signaling pathway and its downstream target genes as well as renal tubular epithelial-mesenchymal transition (EMT), thereby delaying the progression of renal interstitial fibrosis. The Wnt/β-catenin signaling pathway and its downstream target genes may all be the potential regulatory molecules, becoming the potential targets to delay renal interstitial fibrosis. This article reviewed the research progress on inhibition of Wnt/β-catenin signaling pathway to delay renal interstitial fibrosis.

Key words: Renal interstitial fibrosis, Chronic kidney disease, Wnt/β-catenin pathway

Sijia Li, Xiaole Su, Lihua Wang. Progress of research on inhibition of Wnt/β-catenin signaling pathway to delay renal interstitial fibrosis[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2023, 12(04): 224-228.

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URL: https://zhsbyjdzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-3216.2023.04.009

https://zhsbyjdzzz.cma-cmc.com.cn/EN/Y2023/V12/I04/224

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References 45

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