Progress of research on the role of ferroptosis in acute kidney injury caused by nuclear radiation

doi:10.3877/cma.j.issn.2095-3216.2022.06.007

Abstract

Abstract:

In recent years, the research on the relationship between ferroptosis and acute kidney injury (AKI) has been deepening, but the molecular biological mechanism of ferroptosis in AKI caused by nuclear radiation has not been clarified. This article reviewed the progress of research on the role of ferroptosis in the biological process of AKI induced by nuclear radiation so as to look for the potential detection methods and therapeutic targets for treating AKI induced by nuclear radiation.

Key words: Ferroptosis, Acute kidney injury, Nuclear radiation, Glutathione peroxidase, Reactive oxygen species, Lipid peroxides

Yanchen Li, Jianning Li, Xiaowen Tu, Fengsheng Li. Progress of research on the role of ferroptosis in acute kidney injury caused by nuclear radiation[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2022, 11(06): 338-341.

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URL: https://zhsbyjdzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-3216.2022.06.007

https://zhsbyjdzzz.cma-cmc.com.cn/EN/Y2022/V11/I06/338

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References 32

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类型	生理及临床表现	检验结果	影像学结果
亚临床表现	血压升高	血清β2微球蛋白升高	影像学测定GFR下降
	肾脏增大	尿β2微球蛋白升高	^99mTc-DTPA肾小管功能下降
		血清尿素氮升高	^99mTc-DMSA显像肾脏灌注不足
		血清肌酐升高	¹³¹碘核素显像肾脏灌注不足
		肾功能下降	静脉造影剂双肾不对称
		蛋白尿、小管铸型	X射线计算机断层成像肾萎缩
		血尿
		贫血
临床表现	血压高、头痛、恶心	以上均有	以上均有
	水肿、乏力、呼吸困难、昏迷、死亡

类型	生理及临床表现	检验结果	影像学结果
亚临床表现	血压升高	血清β2微球蛋白升高	影像学测定GFR下降
	肾脏增大	尿β2微球蛋白升高	^99mTc-DTPA肾小管功能下降
		血清尿素氮升高	^99mTc-DMSA显像肾脏灌注不足
		血清肌酐升高	¹³¹碘核素显像肾脏灌注不足
		肾功能下降	静脉造影剂双肾不对称
		蛋白尿、小管铸型	X射线计算机断层成像肾萎缩
		血尿
		贫血
临床表现	血压高、头痛、恶心	以上均有	以上均有
	水肿、乏力、呼吸困难、昏迷、死亡

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