Behavioral and emotional disorders in mice with acute kidney injury induced by bilateral renal ischemia reperfusion

doi:10.3877/cma.j.issn.2095-3216.2021.02.003

Abstract

Abstract:

Objective

The purpose of this experiment was to explore the phenotype of brain dysfunction in mice with acute kidney injury.

Methods

The model of bilateral renal ischemia-reperfusion was constructed in C57BL/6J mice. Manifestation changes of the mice with acute kidney injury were observed with the open-field test, tail suspension test, and Barnes maze test. The wild type C57BL/6J mice were used as the control.

Results

Compared with the control group, the model group showed significantly less percentage of center-moving distance in the open-field test, significantly longer total-duration when the motion amplitude was less than the lower limit in the tail suspension test, and significantly shorter total-time of the olfactory region in the Barnes maze test.

Conclusion

The mice with acute kidney injury showed impaired memory function, together with mood disorders of anxiety and depression.

Key words: Acute kidney injury, Brain dysfunction, Phenotype

Ming Gong, Ran Liu, Jiaona Liu, Lingling Wu, Yulan Chen, Jin Wang, Zhe Feng, Li Zhang, Xuefeng Sun, Xiangmei Chen. Behavioral and emotional disorders in mice with acute kidney injury induced by bilateral renal ischemia reperfusion[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2021, 10(02): 70-74.

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Figures/Tables 4

References 25

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