Circular RNAs: new therapeutic target for diabetic kidney disease

doi:10.3877/cma.j.issn.2095-3216.2022.01.008

Abstract

Abstract:

Diabetic kidney disease (DKD) is the most common and serious chronic microvascular complication in diabetic patients, and has become the main cause of end-stage renal disease (ESRD), causing a heavy burden on global public health. Therefore, delaying DKD progression is crucial for reducing the occurrence of ESRD. Studies have shown that circular RNAs (circRNAs) may promote or inhibit glomerulosclerosis and renal tubulointerstitial fibrosis, and aggravate DKD or delay its progression by regulating inflammation, apoptosis, pyroptosis, epithelial-mesenchymal transformation, and so on. This article reviewed the roles of circRNAs in different mechanisms of DKD in order to provide support for finding new targets of DKD treatment.

Key words: Diabetic kidney disease, Circular RNA, Inflammation, Apoptosis, Pyroptosis, Epithelial-mesenchymal transformation

Juan Pan, Xi Qiao. Circular RNAs: new therapeutic target for diabetic kidney disease[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2022, 11(01): 44-47.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhsbyjdzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-3216.2022.01.008

https://zhsbyjdzzz.cma-cmc.com.cn/EN/Y2022/V11/I01/44

Figures/Tables 1

References 43

[1]	Zheng W, Guo J, Liu ZS. Effects of metabolic memory on inflammation and fibrosis associated with diabetic kidney disease: an epigenetic perspective [J]. Clin Epigenetics, 2021, 13(1): 87.
[2]	Adler A, Stevens R, Manley S, et al. Development and progression of nephropathy in type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS 64) [J]. Kidney Int, 2003, 63(1): 225-232.
[3]	Yang C, Wang J, Yang Y, et al. Impact of anemia and chronic kidney disease on the risk of cardiovascular disease and all-cause mortality among diabetic patients [J]. J Peking Univ Health Sci, 2018, 50(3): 495-500.
[4]	Lin X, Xu Y, Pan X, et al. Global, regional, and national burden and trend of diabetes in 195 countries and territories: an analysis from 1990 to 2025 [J]. Sci Rep, 2020, 10(1): 14790.
[5]	Umanath K, Lewis J. Update on diabetic nephropathy: core curriculum 2018 [J]. Am J Kidney Dis, 2018, 71(6): 884-895.
[6]	Saeedi P, Petersohn I, Salpea P, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9 edition [J]. Diabetes Res Clin Pract, 2019, 157: 107843.
[7]	Jin J, Sun H, Shi C, et al. Circular RNA in renal diseases [J]. J Cell Mol Med, 2020, 24(12): 6523-6533.
[8]	Eger N, Schoppe L, Schuster S, et al. Circular RNA splicing [J]. Adv Exp Med Biol, 2018, 1087: 41-52.
[9]	Zhao X, Cai Y, Xu J. Circular RNAs: biogenesis, mechanism, and function in human cancers [J]. Int J Mol Sci, 2019, 20(16): 3926.
[10]	Qu S, Yang X, Li X, et al. Circular RNA: a new star of noncoding RNAs [J]. Cancer Lett, 2015, 365(2): 141-148.
[11]	Kristensen LS, Andersen MS, Stagsted LVW, et al. The biogenesis, biology and characterization of circular RNAs [J]. Nat Rev Genet, 2019, 20(11): 675-691.
[12]	Goldfine A, Shoelson S. Therapeutic approaches targeting inflammation for diabetes and associated cardiovascular risk [J]. J Clin Invest, 2017, 127(1): 83-93.
[13]	Meng X. Inflammatory mediators and renal fibrosis [J]. Adv Exp Med Biol, 2019, 1165: 381-406.
[14]	Shao BY, Zhang SF, Li HD, et al. Epigenetics and inflammation in diabetic nephropathy [J]. Front Physiol, 2021, 12: 649587.
[15]	Tang PC, Zhang YY, Chan MK, et al. The emerging role of innate immunity in chronic kidney diseases [J]. Int J Mol Sci, 2020, 21(11): 4018.
[16]	Mikuda N, Kolesnichenko M, Beaudette P, et al. The IκB kinase complex is a regulator of mRNA stability [J]. EMBO J, 2018, 37(24): e98658.
[17]	Bai Y, Zhang Y, Han B, et al. Circular RNA DLGAP4 ameliorates ischemic stroke outcomes by targeting miR-143 to regulate endothelial-mesenchymal transition associated with blood-brain barrier integrity [J]. J Neurosci, 2018, 38(1): 32-50.
[18]	Wang Q, Cang Z, Shen L, et al. circ_0037128/miR-17-3p/AKT3 axis promotes the development of diabetic nephropathy [J]. Gene, 2021, 765: 145076.
[19]	Hong JN, Li WW, Wang LL, et al. Jiangtang decoction ameliorate diabetic nephropathy through the regulation of PI3K/Akt-mediated NF-κB pathways in KK-Ay mice [J]. Chin Med, 2017, 12: 13.
[20]	Lin M, Tang S. Toll-like receptors: sensing and reacting to diabetic injury in the kidney [J]. Nephrol Dial Transplant, 2014, 29(4): 746-754.
[21]	Panchapakesan U, Pollock C. The role of Toll-like receptors in diabetic kidney disease [J]. Curr Opin Nephrol Hypertens, 2018, 27(1): 30-34.
[22]	Wang Y, Luo W, Han J, et al. MD2 activation by direct AGE interaction drives inflammatory diabetic cardiomyopathy [J]. Nat Commun, 2020, 11(1): 2148.
[23]	Garibotto G, Carta A, Picciotto D, et al. Toll-like receptor-4 signaling mediates inflammation and tissue injury in diabetic nephropathy [J]. J Nephrol, 2017, 30(6): 719-727.
[24]	Feng Q, Liu D, Lu Y, et al. The interplay of renin-angiotensin system and Toll-like receptor 4 in the inflammation of diabetic nephropathy [J]. J Immunol Res, 2020, 2020: 6193407.
[25]	Chen B, Li Y, Liu Y, et al. circLRP6 regulates high glucose-induced proliferation, oxidative stress, ECM accumulation, and inflammation in mesangial cells [J]. J Cell Physiol, 2019, 234(11): 21249-21259.
[26]	Meng X, Nikolic-Paterson D, Lan H. TGF-β：the master regulator of fibrosis [J]. Nat Rev Nephrol, 2016, 12(6): 325-338.
[27]	Xu B, Wang Q, Li W, et al. Circular RNA circEIF4G2 aggravates renal fibrosis in diabetic nephropathy by sponging miR-218 [J]. J Cell Mol Med, 2020, Epub ahead of print.
[28]	Li G, Qin Y, Qin S, et al. Circ_WBSCR17 aggravates inflammatory responses and fibrosis by targeting miR-185-5p/SOX6 regulatory axis in high glucose-induced human kidney tubular cells [J]. Life Sci, 2020, 259: 118269.
[29]	Hu W, Han Q, Zhao L, et al. Circular RNA circRNA_15698 aggravates the extracellular matrix of diabetic nephropathy mesangial cells via miR-185/TGF-beta1 [J]. J Cell Physiol, 2019, 234(2): 1469-1476.
[30]	Schwarzer R, Laurien L, Pasparakis M. New insights into the regulation of apoptosis, necroptosis, and pyroptosis by receptor interacting protein kinase 1 and caspase-8 [J]. Curr Opin Cell Biol, 2020, 63: 186-193.
[31]	Ge X, Xi L, Wang Q, et al. Circular RNA circ_0000064 promotes the proliferation and fibrosis of mesangial cells via miR-143 in diabetic nephropathy [J]. Gene, 2020, 758: 144952.
[32]	Tang B, Li W, Ji TT, et al. Circ-AKT3 inhibits the accumulation of extracellular matrix of mesangial cells in diabetic nephropathy via modulating miR-296-3p/E-cadherin signals [J]. J Cell Mol Med, 2020, 24(15): 8779-8788.
[33]	Hu Y, Gu J, Shen H, et al. Circular RNA LARP4 correlates with decreased Enneking stage, better histological response, and prolonged survival profiles, and it elevates chemosensitivity to cisplatin and doxorubicin via sponging microRNA-424 in osteosarcoma [J]. J Clin Lab Anal, 2020, 34(2): e23045.
[34]	Zhuang L, Wang Z, Hu X, et al. CircHIPK3 alleviates high glucose toxicity to human renal tubular epithelial HK-2 cells through regulation of miR-326/miR-487a-3p/SIRT1 [J]. Diabetes Metab Syndr Obes, 2021, 14: 729-740.
[35]	An L, Ji D, Hu W, et al. Interference of Hsa_circ_0003928 alleviates high glucose-induced cell apoptosis and inflammation in HK-2 cells via miR-151-3p/Anxa2 [J]. Diabetes Metab Syndr Obes, 2020, 13: 3157-3168.
[36]	Lin J, Cheng A, Cheng K, et al. New insights into the mechanisms of pyroptosis and implications for diabetic kidney disease [J]. Int J Mol Sci, 2020, 21(19): 7057.
[37]	Wen S, Li S, Li L, et al. circACTR2: a novel mechanism regulating high glucose-induced fibrosis in renal tubular cells via pyroptosis [J]. Biol Pharm Bull, 2020, 43(3): 558-564.
[38]	Zhang H, Wang Z. Effect and regulation of the NLRP3 inflammasome during renal fibrosis [J]. Front Cell Dev Biol, 2020, 7: 379.
[39]	Wang J, Gao Y, Zhang N, et al. miR-21 overexpression enhances TGF-β1-induced epithelial-to-mesenchymal transition by target smad7 and aggravates renal damage in diabetic nephropathy [J]. Mol Cell Endocrinol, 2014, 392(1-2): 163-172.
[40]	Bartis D, Mise N, Mahida R, et al. Epithelial-mesenchymal transition in lung development and disease: does it exist and is it important? [J]. Thorax, 2014, 69(8): 760-765.
[41]	Liu B, Tang T, Lv L, et al. Renal tubule injury: a driving force toward chronic kidney disease [J]. Kidney Int, 2018, 93(3): 568-579.
[42]	Mou X, Chenv JW, Zhou DY, et al. A novel identified circular RNA, circ_0000491, aggravates the extracellular matrix of diabetic nephropathy glomerular mesangial cells through suppressing miR101b by targeting TGFβRI [J]. Mol Med Rep, 2020, 22(5): 3785-3794.
[43]	Ling L, Tan Z, Zhang C, et al. CircRNAs in exosomes from high glucose-treated glomerular endothelial cells activate mesangial cells [J]. Am J Transl Res, 2019, 11(8): 4667-4682.

Please choose a citation manager

Content to export