Research status of tubular epithelial-mesenchymal transition

doi:10.3877/cma.j.issn.2095-3216.2013.02.010

Abstract

Abstract:

Renal tubular interstitial fibrosis (TIF) is the final common pathway of a wide variety of chronic kidney diseases that eventually lead to end-stage renal disease (ESRD). Growing evidence has implicated tubular epithelial-mesenchymal transition (EMT) as a major pathway leading to TIF in diseased kidneys. Therefore, EMT has become the focus of research in kidney diseases. The purpose of this study is to review the status of renal tubular EMT. It also summarizes the remaining problems and prospects for future research to provide new clues for the study of tubular EMT as well as the treatment of TIF.

Key words: Renal tubule, Epithelial-mesenchymal transition, Renal tubular interstitial fibrosis

Xu-yan LI, Yuan-sheng XIE, Xiang-mei CHEN. Research status of tubular epithelial-mesenchymal transition[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2013, 02(02): 98-102.

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